Skip to Content
Merck

Hypoxia-inducible factors link iron homeostasis and erythropoiesis.

Gastroenterology (2014-01-07)
Yatrik M Shah, Liwei Xie
PMID24389303
ABSTRACT

Iron is required for efficient oxygen transport, and hypoxia signaling links erythropoiesis with iron homeostasis. Hypoxia induces a highly conserved signaling pathway in cells under conditions of low levels of O2. One component of this pathway, hypoxia-inducible factor (HIF), is a transcription factor that is highly active in hypoxic cells. The first HIF target gene characterized was EPO, which encodes erythropoietin-a glycoprotein hormone that controls erythropoiesis. In the past decade, there have been fundamental advances in our understanding of how hypoxia regulates iron levels to support erythropoiesis and maintain systemic iron homeostasis. We review the cell type-specific effects of hypoxia and HIFs in adaptive response to changes in oxygen and iron availability as well as potential uses of HIF modulators for patients with iron-related disorders.

MATERIALS
Product Number
Brand
Product Description
209309
Sigma-Aldrich
Iron, powder, −325 mesh, 97%
267945
Sigma-Aldrich
Iron, chips, 99.98% trace metals basis
356808
Sigma-Aldrich
Iron, foil, thickness 0.1 mm, ≥99.9% trace metals basis
IRMM524B
Iron, IRMM®, certified reference material, 0.5 mm wire
44890
Sigma-Aldrich
Iron, puriss. p.a., carbonyl-Iron powder, low in magnesium and manganese compounds, ≥99.5% (RT)
GF77645953
Iron, foil, light tested, 25x25mm, thickness 0.015mm, 99.85%
GF49120039
Iron, foil, 25x25mm, thickness 1.0mm, as rolled, 99.5%
GF96702644
Iron, foil, not light tested, 50x50mm, thickness 0.01mm, 99.99+%
GF52296419
Iron, rod, 500mm, diameter 40mm, as drawn, armcO« soft ingot 99.8%
GF99892311
Iron, foil, 50x50mm, thickness 0.5mm, hard, 99.5%
GF84532844
Iron, foil, 50x50mm, thickness 0.125mm, as rolled, 99.99+%
GF39321390
Iron, tube, 100mm, outside diameter 10.6mm, inside diameter 10.0mm, wall thickness 0.3mm, as drawn, 99.8+%
GF08067214
Iron, foil, 100x100mm, thickness 2.0mm, as rolled, armco« soft ingot 99.8%
GF72187612
Iron, wire reel, 0.5m, diameter 0.13mm, hard, 99.99+%
GF59202176
Iron, foil, 10m coil, thickness 0.038mm, hard, 99.5%
GF34939345
Iron, tube, 200mm, outside diameter 12.0mm, inside diameter 9mm, wall thickness 1.5mm, annealed, 99.5%
GF44272571
Iron, wire reel, 20m, diameter 0.25mm, hard, 99.5%
GF69970427
Iron, foil, 300x300mm, thickness 0.25mm, hard, 99.5%
GF83584165
Iron, wire reel, 100m, diameter 0.125mm, hard, 99.5%
GF51165884
Iron, tube, 500mm, outside diameter 8.0mm, inside diameter 5mm, wall thickness 1.5mm, annealed, 99.5%
GF89451737
Iron, tube, 200mm, outside diameter 25.0mm, inside diameter 21mm, wall thickness 2mm, annealed, 99.5%
GF63938997
Iron, foil, 300x300mm, thickness 1.0mm, as rolled, armco« soft ingot 99.8%
GF77832355
Iron, tube, 100mm, outside diameter 6.35mm, inside diameter 5.35mm, wall thickness 0.5mm, as drawn, 99.8%
GF25366754
Iron, tube, 100mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.5%
GF48449391
Iron, rod, 1000mm, diameter 12.7mm, as drawn, 98+%
GF93790727
Iron, foil, 10m coil, thickness 0.05mm, hard, 99.5%
GF28189525
Iron, tube, 200mm, outside diameter 12.7mm, inside diameter 9.5mm, wall thickness 1.6mm, annealed, 99.5%
GF27511781
Iron, wire reel, 5m, diameter 0.25mm, annealed, 99.99+%
GF27207109
Iron, wire reel, 2000m, diameter 0.125mm, hard, 99.5%
GF34984659
Iron, foil, 300x300mm, thickness 0.125mm, hard, 99.5%