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Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)

George Psomas, Dimitris P Kessissoglou

ABSTRACT

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Nickel, wire, diam. 0.25 mm, ≥99.9%

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 2400, slurry, in H₂O, active catalyst

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 3202, slurry, in H₂O, active catalyst

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 4200, slurry, in H₂O, active catalyst

Sigma-Aldrich

Nickel, foil, thickness 0.25 mm, 99.995% trace metals basis

Sigma-Aldrich

Nickel, wire, diam. 0.5 mm, ≥99.99% trace metals basis

Sigma-Aldrich

Nickel, foil, thickness 0.125 mm, ≥99.9%

Sigma-Aldrich

Nickel, powder, <1 μm, 99.8% trace metals basis

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 2800, slurry, in H₂O, active catalyst

Sigma-Aldrich

Nickel, powder, <150 μm, 99.99% trace metals basis

Nickel, pellets, 20g, max. size 15mm, 99.99+%

Nickel, foil, 10mm disks, thickness 0.038mm, 99.9%

Nickel, foil, 10m coil, thickness 0.125mm, coil width 1mm, as rolled, 99%

Nickel, wire reel, 100m, diameter 0.25mm, annealed, 99%

Nickel, foil, 200x200mm, thickness 0.1mm, annealed, 99%

Nickel, foil, 4mm disks, thickness 0.038mm, 99.9%

Nickel, foil, 4mm disks, thickness 0.05mm, as rolled, 99.98%

Nickel, foil, 2m coil, thickness 0.15mm, coil width 12mm, annealed, 99%

Nickel, wire reel, 0.1m, diameter 1.0mm, as drawn, 99.99+%

Nickel, foil, 10mm disks, thickness 0.025mm, as rolled, 100%

Nickel, foil, 10m coil, thickness 0.3mm, coil width 1mm, as rolled, 99%

Nickel, foil, 10mm disks, thickness 0.008mm, 99.95%

Nickel, foil, 4mm disks, thickness 0.0075mm, 99.95%

Nickel, wire reel, 1m, diameter 0.75mm, as drawn, 99.99+%

Nickel, foil, 4mm disks, thickness 0.05mm, 99.9%

Nickel, wire reel, 100m, diameter 0.5mm, hard, 99.98%

Nickel, foil, 0.5m coil, thickness 0.25mm, annealed, 99%

Nickel, foil, 0.5m coil, thickness 0.015mm, 99.9%

Nickel, foil, 4mm disks, thickness 0.015mm, 99.9%

Nickel, wire reel, 10m, diameter 0.025mm, as drawn, 99.6+%