SOST
sclerostin
Synonyms:
CDD, VBCH
Species:
Human SOST (50964), Mouse Sost (74499), Rat Sost (80722), dog SOST (490948), chicken SOST (429784), Zebrafish sost (100000500), domestic cat SOST (101083725), naked mole-rat Sost (101719889), domestic guinea pig Sost (100730713), sheep SOST (101114123)
UniProtKB ID:
Gene ID:
- Human(50964) Summary: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
- Mouse(74499) sclerostin
- Rat(80722) sclerostin
- dog(490948) sclerostin
- chicken(429784) sclerostin
- Zebrafish(100000500) sclerostin
- domestic cat(101083725) sclerostin
- naked mole-rat(101719889) sclerostin
- domestic guinea pig(100730713) sclerostin
- sheep(101114123) sclerostin
- cow(282880) sclerostin
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