Merck
All Photos(3)

1.37148

SAFC

Triethanolamine

EMPROVE® EXPERT, Ph. Eur., NF

Synonym(s):
2,2′,2′′-Nitrilotriethanol, Tris(2-hydroxyethyl)amine
Linear Formula:
(HOCH2CH2)3N
CAS Number:
Molecular Weight:
149.19
Beilstein:
1699263
MDL number:

Agency

NF
Ph. Eur.

Quality Level

vapor density

5.14 (vs air)

vapor pressure

0.01 mmHg ( 20 °C)

product line

EMPROVE® EXPERT

form

liquid

autoignition temp.

600 °F

expl. lim.

8.5 %

refractive index

n20/D 1.485 (lit.)

useful pH range

7.3-8.3

pKa (25 °C)

7.8

bp

190-193 °C/5 mmHg (lit.)

mp

17.9-21 °C (lit.)

density

1.124 g/mL at 25 °C (lit.)

application(s)

liquid formulation
pharmaceutical
semi-solid formulation

storage temp.

2-25°C

SMILES string

OCCN(CCO)CCO

InChI

1S/C6H15NO3/c8-4-1-7(2-5-9)3-6-10/h8-10H,1-6H2

InChI key

GSEJCLTVZPLZKY-UHFFFAOYSA-N

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Triethanolamine (Trolamine) is a tertiary amine that acts as a basic buffer component, typically used as a final formulation buffer for small molecules pharmaceuticals. It may also be used as a process buffer in cell lysis and biomolecule downstream chromatography.
As a multi-compendial product, Triethanolamine (Trolamine) Emprove® Expert meets the N-nitrosodiethanolamine limits required by Ph Eur. Also, low microbial and endotoxin limits facilitate the use of this product in high-risk applications.

Packaging

1 L in glass bottle
25 L in stainless steel drum

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

354.2 °F - closed cup

Flash Point(C)

179 °C - closed cup

Certificate of Analysis

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Certificate of Quality

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What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Material Qualification Dossier

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Quality Management Dossier

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Operational Excellence Dossier

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Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

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