03557

Poly(ethylene glycol)

tested according to Ph. Eur., 35,000

• Synonym(s): Macrogol 35,000, PEG
• Linear Formula: H(OCH₂CH₂)_nOH
• CAS Number: 25322-68-3
• MDL number: MFCD00081839
• PubChem Substance ID: 24845502
• NACRES: NA.21

Properties

• Agency: tested according to Ph. Eur.
• Quality Level: 200
• form: powder
• mol wt: ~35000
• solubility: aliphatic hydrocarbons: slightly soluble; organic solvents: soluble
• application(s): pharmaceutical (small molecule)
• SMILES string: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• InChI key: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

Application

Poly (ethylene glycol) can be used as a test compound utilized in the overproduction and purification of recombinant Lactobacillus reuteri LrNDT. It can also be used for concentrating the mutants with lower secretion levels used in ELISAs for the quantitation of shgp190 and of the LIF/shgp190 complexes.

Biochem/physiol Actions

Polyethylene glycol (PEG) is a condensation polymer of ethylene oxide and water. It enhances the refolding of extracted proteins. This enables characterization of crystallized proteins.

Preparation Note

Poly(ethylene glycol) dissolves in many organic solvents and is readily soluble in aromatic hydrocarbons. It also slightly dissolves in aliphatic hydrocarbons.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 281.5 °F - closed cup
• Flash Point(C): 138.6 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves