Regulatory toxicology and pharmacology : RTP, 14(1), 59-77 (1991-08-01)
Regulatory agencies traditionally use doses associated with ambient concentrations of contaminants in environmental media to estimate lifetime excess cancer risks. This approach is, however, limited by the errors inherent in making several default assumptions such as daily water and food
Environmental monitoring and assessment, 186(4), 2399-2412 (2013-12-18)
A new method has been developed to determine heptachlor and its metabolites heptachlor-exo-epoxide and heptachlor-endo-epoxide in pork. The pork samples were extracted with acetone-n-hexane (2:8, V:V) and cleaned up by gel permeation chromatography and florisil solid-phase extraction cartridge. The extract
Reviews of environmental contamination and toxicology, 111, 61-142 (1990-01-01)
The chlorinated cyclodiene heptachlor was registered in 1952 as an agricultural and domestic insecticide. By early 1984, registration for all purposes, except subterranean termite control and for limited use in the control of fire ants, had been cancelled. This restriction
Bioconcentration factors (BCFs) measured in the laboratory are important for characterizing the bioaccumulative properties of chemicals entering the environment, especially the potential persistent organic pollutants (POPs), which can pose serious adverse effects on ecosystem and human health. Traditional lethal analysis
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 7(3), 85-114 (1987-01-01)
Heptachlor and its metabolite heptachlor epoxide are unequivocally carcinogenic in rats and mice. The chemicals induced carcinomas of the liver, which were highly significant. There were neoplasms at other sites in rats. Neoplasms at all sites, as well as malignant
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