Merck
All Photos(2)

41019

Supelco

Melting point standard 235-237°C

analytical standard

Synonym(s):
Caffeine, 1,3,7-Trimethylxanthine
Empirical Formula (Hill Notation):
C8H10N4O2
CAS Number:
Molecular Weight:
194.19
Beilstein:
17705
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

shelf life

limited shelf life, expiry date on the label

mp

234-236.5 °C (lit.)
235-237 °C (±0.3°C)

application(s)

food and beverages
pharmaceutical

format

neat

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

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1 of 4

This Item
75035PHR1095PHR1009
Caffeine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1009

Caffeine

grade

analytical standard

grade

analytical standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

mp

234-236.5 °C (lit.), 235-237 °C (±0.3°C)

mp

234-236.5 °C (lit.)

mp

~Approximately 237 °C, 234-236.5 °C (lit.)

mp

234-236.5 °C (lit.)

application(s)

food and beverages
pharmaceutical

application(s)

cleaning products
food and beverages
personal care
pharmaceutical

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

shelf life

limited shelf life, expiry date on the label

shelf life

limited shelf life, expiry date on the certificate and label

shelf life

-

shelf life

-

Quality Level

100

Quality Level

100

Quality Level

300

Quality Level

300

General description

Melting point standard 235-237 °C, caffeine is useful to calibrate melting point instruments, in the thermodynamic mode of measurement. The value of its melting point is determined with an average of 6 to 12 measurements using a Büchi B-545 instrument that is calibrated against primary standards.

Application

Caffeine melting point standard 235-237 °C finds its use in the characterization of pure chemicals and pharmaceutical compounds.

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Features and Benefits

  • Melting point calibration standard traceable to primary standards (LGC, London)
  • Grade: Analytical Standard
  • Standard deviation up to ± 0.3 °C
  • Provided with certificates of analysis and safety data sheet

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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