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PHR1000

Supelco

Dextrose

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
D-(+)-Glucose, Dextrose
Empirical Formula (Hill Notation):
C6H12O6
CAS Number:
Molecular Weight:
180.16
Beilstein:
1724615
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. Y0001745
traceable to USP 1181302

API family

dextrose

Assay

99.9%

CofA

current certificate can be downloaded

analyte chemical class(es)

oligosaccharides

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

150-152 °C (lit.)

application(s)

detection
food and beverages
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1

InChI key

WQZGKKKJIJFFOK-DVKNGEFBSA-N

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This Item
D94341181302G3285
Dextrose Pharmaceutical Secondary Standard; Certified Reference Material

PHR1000

Dextrose

Dextrose 97.5-102.0% anhydrous basis, meets EP, BP, JP, USP testing specifications

D9434

Dextrose

Dextrose United States Pharmacopeia (USP) Reference Standard

1181302

Dextrose

D-(+)-Glucose solution 1 mg/mL in 0.1% benzoic acid, standard for enzymatic assay kits GAGO20, GAHK20, STA20, analytical standard

G3285

D-(+)-Glucose solution

application(s)

detection
food and beverages
pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

food and beverages
general analytical

format

neat

format

-

format

neat

format

-

Quality Level

300

Quality Level

200

Quality Level

-

Quality Level

100

grade

certified reference material, pharmaceutical secondary standard

grade

anhydrous

grade

pharmaceutical primary standard

grade

analytical standard

assay

99.9%

assay

97.5-102.0% anhydrous basis

assay

-

assay

-

General description

Dextrose belongs to the class of sugars, and is a preferred source of carbohydrate in parenteral nutrition regimens. It is widely used in solutions to adjust tonicity, as a sweetening agent, wet granulation diluent/binder, direct-compression tablet diluent/binder, etc. It is considered only for short term clinical use, since it is deficient in electrolytes.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Dextrose has been used as a standard in the determination of additives like glucose in beverages using high performance liquid chromatography (HPLC). It may also be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7785 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1


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Dextrose monohydrate meets USP testing specifications, 97.5-102.0% anhydrous basis

Sigma-Aldrich

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A multicommuted flow system for the determination of dextrose in parenteral and hemodialysis concentrate solutions
Knochen M, et al. et al.
Journal of Pharmaceutical and Biomedical Analysis, 37(4), 823-828 (2005)
Handbook of Pharmaceutical Excipients (1986)
Handbook of Starch Hydrolysis Products and their Derivatives (1995)
Saunders Handbook of Veterinary Drugs - E-Book: Small and Large Animal (2010)
Determination of Additives in Beverages Using Ascentis Express Columns
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Sigma data, 30 (2013)

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