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PHR1013

Supelco

Salicylic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
2-Hydroxybenzoic acid
Linear Formula:
2-(HO)C6H4CO2H
CAS Number:
Molecular Weight:
138.12
Beilstein:
774890
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

4.8 (vs air)

vapor pressure

1 mmHg ( 114 °C)

CofA

current certificate can be downloaded

application(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

211 °C (lit.)

mp

158-161 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to BP 775
traceable to PhEur S020000
traceable to USP 1609002

SMILES string

OC(=O)c1ccccc1O

InChI

1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

InChI key

YGSDEFSMJLZEOE-UHFFFAOYSA-N

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General description

Salicylic acid is an important material in pharmaceutical industry, obtained via the decomposition of acetylsalicylic acid. Salicylic acid is widely used in food industry for producing dyes and artificial scents. It also shows therapeutic potential in protecting the skin from sun damage and hence finds applications in cosmetics and medicine.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Salicylic acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrofluorometric technique.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3036 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

314.6 °F - closed cup

Flash Point(C)

157 °C - closed cup

Certificate of Analysis

Certificate of Origin

Nickel?aluminum layered double hydroxide as a nanosorbent for selective solid-phase extraction and spectrofluorometric determination of salicylic acid in pharmaceutical and biological samples
Abdolmohammad-Zadeh H, et al.
Talanta, 84(2), 368-373 (2011)
Simultaneous determination of naproxen, salicylic acid and acetylsalicylic acid by spectrofluorimetry using partial least-squares (PLS) multivariate calibration
Navalon A, et al.
Talanta, 48(2), 469-475 (1999)
E Benfeldt et al.
Acta dermato-venereologica, 79(5), 338-342 (1999-09-24)
Our aim was to simultaneously investigate 2 techniques for in vivo sampling of peripheral compartment pharmacokinetics after systemic administration of acetylsalicylic acid. Ten volunteers were given 2 g acetylsalicylic acid orally. Blood samples and dialysates from 4 microdialysis probes inserted...
Andrea Clavijo McCormick et al.
Plant, cell & environment, 37(8), 1909-1923 (2014-01-30)
After herbivory, plants release volatile organic compounds from damaged foliage as well as from nearby undamaged leaves that attract herbivore enemies. Little is known about what controls the volatile emission differences between damaged and undamaged tissues and how these affect...
Caroline Gutjahr et al.
Molecular plant-microbe interactions : MPMI, 22(7), 763-772 (2009-06-16)
Work on the interaction of aerial plant parts with pathogens has identified the signaling molecules jasmonic acid (JA) and salicylic acid (SA) as important players in induced defense of the plant against invading organisms. Much less is known about the...

Protocols

HPLC Analysis of Aspirin and Salicylic Acid on Ascentis® Express RP-Amide

Separation of Acetylsalicylic acid, analytical standard; Salicylic acid, BioXtra, ≥99.0%

HPLC Analysis of Salicylic Acid and Acetylsalicylic Acid (Aspirin) on Ascentis® Express OH5

Separation of Salicylic acid, meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance); Acetylsalicylic acid, purum, ≥99.0% (HPLC)

HPLC Analysis of Benzoic Acid and Related Compounds on Ascentis® RP-Amide

Separation of 4-Hydroxybenzoic acid; Acetylsalicylic acid; Benzoic acid; Salicylic acid; Ethyl 4-hydroxybenzoate

HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18

HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18

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