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PHR1050

Supelco

Benzoic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Linear Formula:
C6H5COOH
CAS Number:
Molecular Weight:
122.12
Beilstein:
636131
EC Number:
MDL number:
eCl@ss:
39023903
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

4.21 (vs air)

vapor pressure

10 mmHg ( 132 °C)

form

neat

CofA

current certificate can be downloaded

autoignition temp.

1061 °F

application(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

249 °C (lit.)

mp

121-125 °C (lit.)

Featured Industry

Cleaning Products
Cosmetics
Food and Beverages
Personal Care
Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1055002

SMILES string

OC(=O)c1ccccc1

InChI

1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)

InChI key

WPYMKLBDIGXBTP-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Benzoic acid may be used as a reference standard in determining the concentration of benzoic acid in food and milk samples using high performance liquid chromatography coupled with photodiode array detector (HPLC).

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB8257 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

CorrosionHealth hazard

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT RE 1 Inhalation

Target Organs

Lungs

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Germany

WGK 1

Certificate of Analysis

Certificate of Origin

Determination of benzoic and sorbic acids in Brazilian food
Tfouni.V.A.S and Toledo F.C.M
Food Control, 13, 117-123 (2002)
Determination of benzoic and sorbic acids in Brazilian food
Qi P, et al.
Food Control, 20, 414-418 (2009)
S Nacht et al.
Journal of the American Academy of Dermatology, 4(1), 31-37 (1981-01-01)
The transepidermal penetration and metabolic disposition of 14C-benzoyl peroxide were assessed in vitro (excised human skin) and in vivo (rhesus monkey). In vitro, the benzoyl peroxide penetrated into the skin, through the stratum corneum or the follicular openings, or both...
G C Tremblay et al.
Pharmacology & therapeutics, 60(1), 63-90 (1993-10-01)
Detoxification of sodium benzoate by elimination as a conjugate with glycine, a nonessential amino acid, provides a pathway for the disposal of waste nitrogen. Since 1979, sodium benzoate has been widely used in the therapeutic regimen to combat ammonia toxicity...
Renbo Wei et al.
Macromolecular rapid communications, 34(4), 330-334 (2013-01-03)
A new approach is developed to fabricate highly oriented mono-domain LCE nano/microstructures through micro-molding in capillaries. Gratings and microwires as two typical examples are fabricated and characterized by polarizing optical microscopy, optical microscopy, and scanning electron microscopy. The gratings with...

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