Merck
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W450001

Sigma-Aldrich

Choline chloride

FCC

Synonym(s):
(2-Hydroxyethyl)trimethylammonium chloride
Linear Formula:
(CH3)3N(Cl)CH2CH2OH
CAS Number:
Molecular Weight:
139.62
FEMA Number:
4500
Beilstein:
3563126
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

biological source

synthetic

grade

Halal
Kosher

reg. compliance

FCC
FDA 21 CFR 117

form

powder, crystals or chunks

color

white

mp

302-305 °C (dec.) (lit.)

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

Organoleptic

fishy

SMILES string

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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General description

Choline chloride (ChCl) is a quaternary ammonium salt. The unusual solvent properties of eutectic mixtures of urea and choline chloride make it useful as a biodegradable ambient-temperature solvent for a number of applications; such as a reaction medium for the synthesis of coordination polymer: Zn(O3PCH2CO2)].NH4. Ethylene glycol/choline chloride and urea based eutectic solvents can be used for the electrodeposition of Zn, Sn and Zn/Sn alloys. Choline chloride.xZnCl2 participates as a catalyst during the reaction between benzaldehyde and neopentyl glycol.

Application

Choline chloride may be used as an analytical reference standard for the determination of choline in biological fluids and dairy products by high-throughput method based on normal-phase chromatography−tandem mass spectrometry and flow injection analysis and amperometric detection with a choline oxidase based biosensor, respectively.

Packaging

1 kg in poly bottle
5 kg in poly drum

Biochem/physiol Actions

The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Substrates

Choline acetyltransferase substrate

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Andrew P Abbott et al.
Physical chemistry chemical physics : PCCP, 11(21), 4269-4277 (2009-05-22)
Here we describe for the first time the electrolytic deposition of copper and copper composites from a solution of the metal chloride salt in either urea-choline chloride, or ethylene glycol-choline chloride based eutectics. We show that the deposition kinetics and
Determination of choline in milk, milk powder, and soy lecithin hydrolysates by flow injection analysis and amperometric detection with a choline oxidase based biosensor
Pati S, et al.
Journal of Agricultural and Food Chemistry, 52(15), 4638-4642 (2004)
Andrew P Abbott et al.
Chemical communications (Cambridge, England), (1)(1), 70-71 (2003-03-04)
Eutectic mixtures of urea and a range of quaternary ammonium salts are liquid at ambient temperatures and have interesting solvent properties.
Eutectic mixture of choline chloride/urea as a green solvent in synthesis of a coordination polymer:[Zn (O 3 PCH 2 CO 2)]? NH 4.
Liao JH, et al.
Inorganic Chemistry Communications, 8(4), 390-392 (2005)
Green and moisture-stable Lewis acidic ionic liquids (choline chloride.xZnCl2) catalyzed protection of carbonyls at room temperature under solvent-free conditions.
Duan Z, et al.
Catalysis Communications, 7, 651-656 (2006)

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