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A1852

Sigma-Aldrich

Adenosine 5′-triphosphate (ATP) disodium salt hydrate

vial of 30 mg

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Synonym(s):
ATP disodium hydrate
Linear Formula:
C10H14N5O13P3Na2 · xH2O
CAS Number:
Molecular Weight:
551.14 (anhydrous basis)
EC Number:
MDL number:
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51

biological source

microbial (Corynebacterium sp.)

Assay

≥99% (HPLC)

form

powder

packaging

vial of 30 mg

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

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This Item
FLAASA2383A3377
assay

≥99% (HPLC)

assay

≥90%

assay

≥99%

assay

≥97% (HPLC)

form

powder

form

lyophilized powder

form

powder

form

crystalline

packaging

vial of 30 mg

packaging

vial of ~1 mg ATP

packaging

-

packaging

-

solubility

water: 50 mg/mL, clear, colorless

solubility

-

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Adenosine 5γ-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger CAMP. ATP provides the metabolic energy to drive metabolic pumps.

Application

ATP serves as a coenzyme in a wide array of enzymatic reactions.Adenosine 5′-triphosphate (ATP) disodium salt hydrate is used for tissue preparation and maintenance.
Adenosine 5′-triphosphate (ATP) disodium salt hydrate has been used:
  • in rat hippocampal slice cultures to mimic synaptic signalling
  • in the isolation of plasmid from primary porcine alveolar macrophages (PAMs)
  • as a component of hot reaction kinase buffer for in gel kinase assay

Biochem/physiol Actions

P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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NS1 protein of 2009 pandemic influenza A virus inhibits porcine NLRP3 inflammasome-mediated interleukin-1 beta production by suppressing ASC ubiquitination
Park HS, et al.
Journal of Virology, JVI-00022 (2018)
Bio-Protocol
Pizzio GA and Rodriguez PL
Testing, 7(5) (2017)
Mark D A van Logtestijn et al.
PloS one, 10(2), e0117292-e0117292 (2015-02-12)
The stratum corneum (SC) provides a permeability barrier that limits the inflow and outflow of water. The permeability barrier is continuously and dynamically formed, maintained, and degraded along the depth, from the bottom to the top, of the SC. Naturally
JuanJuan Duan et al.
Cellular signalling, 58, 44-52 (2019-03-12)
Persistent inflammasome activation contributes to chronic, low grade inflammation. However, it is unclear how the inflammasome activation is sustained after initiation. Here we reported that N4-acetylcytidine (N4A), a nucleoside metabolite, activated microglia and sustained NLRP3 inflammasome activation by inducing HMGB1
Stephani Velasquez et al.
EBioMedicine, 51, 102503-102503 (2019-12-07)
In developed countries, Human Immunodeficiency Virus type-1 (HIV-1) infection has become a chronic disease despite the positive effects of anti-retroviral therapies (ART), but still at least half of the HIV infected population shown signs of cognitive impairment. Therefore, biomarkers of

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