A5376
synthetic
≥99.0%
powder
white
3.5
134-136 °C (lit.)
H2O: 10 mg/mL at 37 °C(lit.)
H2O: 3 mg/mL at 25 °C(lit.)
ethanol: 50 mg/mL
aqueous base: decomposes
190 at 298 nm in aqueous base at 1 mM
409 at 231 nm in aqueous base at 1 mM
466 at 230 nm in aqueous acid at 1 mM
68 at 278 nm in aqueous acid at 1 mM
CC(=O)Oc1ccccc1C(O)=O
1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
BSYNRYMUTXBXSQ-UHFFFAOYSA-N
human ... ITGA2B(3674) , ITGB3(3690) , PTGS1(5742) , PTGS2(5743)
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Warning
Acute Tox. 4 Oral
11 - Combustible Solids
WGK 1
482.0 °F
250 °C
dust mask type N95 (US), Eyeshields, Gloves
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There may be multiple modes of action which result in the anticlotting properties of aspirin. Some studies have indicated a decrease in thrombin levels and others reduced clotting properties of fibrinogen.
The active ingredient acetylsalicylic acid offered by Sigma-Aldrich is the same chemical as found in aspirin tablets. However, chemicals for pharmaceutical use are manufactured, tested, and packaged under the regulation of the FDA, but chemicals sold for research use do not have the same regulatory oversight.
Acetylsalicylic acid is slightly soluble in water, with a limit of solubility reported as approximately 3 mg/ml at 25 Deg C. It is also soluble in ethanol at 50 mg/ml and will dissolve in solutions of alkali hydroxides and carbonates with decomposition. Aqueous solutions of acetylsalicylic acid are most stable at pH 2 - 3, but to assure full activity, fresh solutions are recommended.
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