Merck
All Photos(1)

A5835

Sigma-Aldrich

γ-Aminobutyric acid

BioXtra, ≥99%

Synonym(s):
3-Carboxypropylamine, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid
Linear Formula:
NH2(CH2)3COOH
CAS Number:
Molecular Weight:
103.12
Beilstein:
906818
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.26

product line

BioXtra

Quality Level

assay

≥99%

form

powder

technique(s)

ligand binding assay: suitable

impurities

<0.0005% Phosphorus (P)
<0.1% Insoluble matter

ign. residue

<0.1%

color

white

mp

195 °C (dec.) (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): <0.04%
sulfate (SO42-): <0.05%

cation traces

Al: <5 mg/kg
Ca: <20 mg/kg
Cu: <5 mg/kg
Fe: <5 mg/kg
K: <50 mg/kg
Mg: <50 mg/kg
NH4+: <500 mg/kg
Na: <70 mg/kg
Pb: <10 mg/kg
Zn: <5 mg/kg

SMILES string

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

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General description

γ-Aminobutyric acid (GABA) is a non-protein amino acid associated with the brain. Being synthesized in the nervous system, it is packed into synaptic vesicles. It is present naturally in green tea, soybean,[1] germinated rice, and in some fermented foods.[2]

Application

γ-Aminobutyric acid (GABA) has been used to treat dorsal root ganglion neurons for electrophysiological recordings studies to test its effect on neuropathic pain in rats.[3] It has also been used to test its protective effects in an ex vivo machine perfusion system of small-for-size grafts (SFSG) injury model.[4]

Packaging

10 mg in autosample vial

Biochem/physiol Actions

γ-Aminobutyric acid (GABA) is a mammalian inhibitory neurotransmitter with multiple functions.[1] It is crucial for the normal central nervous system (CNS) functioning.[2] A few documented functions of GABA include its protective role in toxin-induced damage. It also elicits anti-hypertensive, anti-diabetic, anti-microbial, antioxidant, anti-allergy, anti-inflammatory, and anti-cancer effects.[1] GABA might show beneficial effects on stress and sleep in humans.[2] γ-Aminobutyric acid (GABA) is used to study the biological and biochemical processes mediated via the GABA receptors, GABAA and GABAB.[1]
Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl conductance.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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