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B1651

Sigma-Aldrich

Bradykinin Fragment 1-7

≥97% (HPLC)

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Synonym(s):
1-7-Bradykinin
Empirical Formula (Hill Notation):
C35H52N10O9
CAS Number:
23815-87-4
Molecular Weight:
756.85
MDL number:
MFCD00076262
PubChem Substance ID:
24891606
NACRES:
NA.26

Quality Level

200

Assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P01161

storage temp.

−20°C

SMILES string

NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(O)=O

InChI

1S/C35H52N10O9/c36-22(10-4-14-39-35(37)38)31(50)44-16-6-12-26(44)33(52)43-15-5-11-25(43)30(49)40-19-28(47)41-23(18-21-8-2-1-3-9-21)29(48)42-24(20-46)32(51)45-17-7-13-27(45)34(53)54/h1-3,8-9,22-27,46H,4-7,10-20,36H2,(H,40,49)(H,41,47)(H,42,48)(H,53,54)(H4,37,38,39)

InChI key

CRROPKNGCGVIOG-UHFFFAOYSA-N

Gene Information

rat ... Nppa(24602)

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This Item
S6272B1401B1901
Bradykinin Fragment 1-7 ≥97% (HPLC)

Sigma-Aldrich

B1651

Bradykinin Fragment 1-7

Substance P Fragment 1-7 ≥97% (HPLC)

Sigma-Aldrich

S6272

Substance P Fragment 1-7

Bradykinin Fragment 1-5 ≥97% (HPLC)

Sigma-Aldrich

B1401

Bradykinin Fragment 1-5

Bradykinin Fragment 2-9 ≥97% (HPLC)

Sigma-Aldrich

B1901

Bradykinin Fragment 2-9

form

powder

form

powder

form

powder

form

powder

color

white

color

white

color

-

color

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

UniProt accession no.

P01161

UniProt accession no.

P20366

UniProt accession no.

P01042

UniProt accession no.

P01042

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro

General description

Bradykinin fragment 1-7 (BK-(1-7)), an endogenous peptide, is present in plasma.

Application

Bradykinin Fragment 1-7 has been used as an external calibrant/standard in the matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis of protein spots.
Bradykinin Fragment 1-7 is used in research on the specificity and kinetics of kininase(s).

Biochem/physiol Actions

Bradykinin (BK) is a pro-inflammatory mediator and a neuromediator. It modulates several vascular and renal functions. Bradykinin (BK) plays a key role in inducing vascular permeability and mitogenesis. It helps to activate the liberation of nitric oxide in inflammatory and cancer tissues.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Laura M Jones et al.
Journal of proteome research, 9(6), 2871-2881 (2010-04-16)
The insulin/insulin-like growth factor-1 (IGF-1) signaling system is a public regulator of aging in the model animals Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus. For the first time, proteomic analyses of the environmentally resistant and 'nonaging' C. elegans dauer stage
M Bramucci et al.
Acta physiologica Scandinavica, 175(2), 123-128 (2002-05-25)
Angiotensin converting enzyme (ACE) was demonstrated to modulate the production of 17beta-estradiol, progesterone and prostaglandin E2 (PGE2) in frog ovary of Rana esculenta. However, the activity was not mediated by angiotensin II (Ang II). In an attempt to identify the
J M Ribeiro et al.
Experimental parasitology, 89(2), 213-221 (1998-06-27)
Saliva and salivary gland homogenates of Ixodes scapularis contain a dipeptidyl carboxypeptidase activity that accounts for the previously described salivary kininase activity of this tick. Reversed phase HPLC and laser desorption mass spectrography of the reaction products identified bradykinin fragment
Peptide fragments of bradykinin show unexpected biological activity not mediated by B1 or B2 receptors
Souza SI, et al.
15th international conference on miniaturized systems for chemistry and life sciences, Seattle, Washington (2021)
Measurement of des-Phe8-Arg9-bradykinin by enzyme-immunoassay--a useful parameter of plasma kinin release.
M Majima et al.
Advances in experimental medicine and biology, 247B, 331-335 (1989-01-01)
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