Merck
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C1188

Sigma-Aldrich

Collagen from bovine tracheal cartilage

Bornstein and Traub Type II, powder

CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

Quality Level

biological source

bovine cartilage (tracheal)

form

powder

solubility

aqueous acid: soluble

UniProt accession no.

storage temp.

2-8°C

Gene Information

General description

Collagen protein is abundantly present in human. It is the prime structural constituent of dermis. It is also an important constituent of extracellular matrix (ECM).
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Application

Collagen from bovine tracheal cartilage has been used to induce arthritis in male DBA/1 mice. It has also been used as a fluorophore to acquire fluorescence emission spectra on the reflectance and fluorescence lifetime spectrometer (RFLS).
Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type II. Collagen-type II has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.

Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.

Packaging

5 mg in glass bottle
10 mg in poly bottle

Biochem/physiol Actions

Collagen participates in the aging process. It offers a structural framework for cells and mechanical strength to tissues.

Preparation Note

Prepared by a modification of the pepsin extraction procedure of Trentham, et al., J. Exp. Med., 146, 857 (1977).

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

Quotes and Ordering

Quantitative molecular sensing in biological tissues: an approach to non-invasive optical characterization
Chandra M, et al.
Optics Express, 14(13), 6157-6171 (2006)
Molecular and cellular basis of hypertrophic scarring
Total Burn Care, 495-505 (2012)
Important role of interleukin-3 in the early phase of collagen-induced arthritis
Bruhl H, et al.
Arthritis and Rheumatism, 60(5), 1352-1361 (2009)
Rosalia Cuahtecontzi Delint et al.
Biomaterials, 276, 120996-120996 (2021-07-20)
One of the major challenges within the emerging field of injectable stem cell therapies for articular cartilage (AC) repair is the retention of sufficient viable cell numbers at the site of injury. Even when delivered via intra-articular injection, the number
A J Freemont et al.
Annals of the rheumatic diseases, 58(6), 357-365 (1999-05-26)
Chondrocytic matrix metalloproteinases (MMPs) are believed to be important in osteoarthritic cartilage degradation. The cartilage lesion of osteoarthritis (OA) is focal and often progressive. During its development chondrocytes differentially up and down regulate production of mRNA for individual MMPs. This

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