Merck
All Photos(3)

C1879

Sigma-Aldrich

Choline chloride

≥98%

Synonym(s):
(2-Hydroxyethyl)trimethylammonium chloride
Linear Formula:
(CH3)3N(Cl)CH2CH2OH
CAS Number:
Molecular Weight:
139.62
Beilstein:
3563126
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

biological source

synthetic

assay

≥98%

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

color

colorless to white

mp

302-305 °C (dec.) (lit.)

SMILES string

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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General description

Choline chloride is the synthetic form of vitamin B4, choline and is a common poultry feed.

Application

Choline chloride has been used:
  • as a substrate for measuring choline oxidase enzyme activity using fluorescence measurements
  • as a component of non-physiological buffers for testing calcium based inhibition of cytochrome c oxidaseP
  • as a component of perfusate solution for studying arterial pressure in jejunum samples

Packaging

500 g in poly bottle
1, 5 kg in poly drum

Biochem/physiol Actions

Choline chloride treatment of radish seeds modulates phosphatidylcholine and phosphatidylethanolamine levels. It elicits hepatoprotective effects and modulates methyl carbon based metabolic pathways.
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Substrates

Choline acetyltransferase substrate

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Choline and methionine differentially alter methyl carbon metabolism in bovine neonatal hepatocytes
Chandler TL and White HM
PLoS ONE, 12(2), e0171080-e0171080 (2017)
Effect of choline chloride on the lipid content and composition in the leaves of principal magnetically-oriented radish types
Novitskaya GV, et al.
Russian Journal of Plant Physiology, 51(3), 361-371 (2004)
Cytochrome c oxidase inhibition by calcium at physiological ionic composition of the medium: Implications for physiological significance of the effect
Vygodina T, et al.
Biochimica et Biophysica Acta - Bioenergetics, 1858(12), 982-990 (2017)
Rapid enzymatic method for the determination of phosphoryl choline using the fluorescence of the enzyme choline oxidase. Sequential determination of choline and phosphorylcholine in milk powder for children
Sanz-Vicente I, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 123, 259-266 (2015)
An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat
Lucas ML and Morrison JD
Physiological Reports, 3(5) (2015)

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