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C7017

Sigma-Aldrich

Choline chloride

≥99%

Synonym(s):
(2-Hydroxyethyl)trimethylammonium chloride
Linear Formula:
(CH3)3N(Cl)CH2CH2OH
CAS Number:
Molecular Weight:
139.62
Beilstein:
3563126
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

biological source

synthetic

assay

≥99%

form

powder

color

white

mp

302-305 °C (dec.) (lit.)

SMILES string

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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General description

Choline is a constituent of sphingomyelin and lecithin. It is a precursor of acetylcholine. Choline plays a vital role in methyl group metabolism, carcinogenesis and lipid transport. Choline deficiency is associated with fatty liver. It maintains cell structural integrity and cell signalling. Choline is implicated in the synthesis of phospholipids. It acts as a potent biomarker for ischemic heart disease.

Application

Choline chloride has been used:
  • in choline release assay
  • as an endogenous agonist of sigma-1 receptors (Sig-1Rs)
  • as a standard to analyse interrelationships between methionine and choline metabolism

Packaging

10 mg in autosample vial
5, 25, 100 g in glass bottle

Biochem/physiol Actions

The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .
Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.

Substrates

Choline acetyltransferase substrate

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Clinical biochemistry of domestic animals (2008)
Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain
Thirunavukkarasu K, et al.
Osteoarthritis and Cartilage, 25(6), 935-942 (2017)
Encyclopedia of Food Sciences and Nutrition (Second Edition) (2003)
Pathophysiological roles and clinical importance of biomarkers in acute coronary syndrome
Chan CP and Rainer TH
Advances in Clinical Chemistry, 59, 23-63 (2013)
Rumen-protected choline for dairy cows: the in situ evaluation of a commercial source and literature evaluation of effects on performance and interactions between methionine and choline metabolism
Brusemeister F and Sudekum KH
Animal Research, 55(2), 93-104 (2006)

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