Merck
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C7806

Sigma-Aldrich

Collagen from bovine nasal septum

Bornstein and Traub Type II, powder

Synonym(s):
Collagen from bovine
CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

biological source

bovine nasal septum

Quality Level

form

powder

technique(s)

ELISA: suitable

solubility

aqueous acid: soluble

UniProt accession no.

storage temp.

2-8°C

Gene Information

bovine ... COL2A1(407142)

General description

Collagen is a fibrous protein, found in connective tissues, hard tissues, bone, dentin, cementum and also the mineralizing cartilage of the epiphyseal growth plate.
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Application

Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type 2. Collagen-type 2 has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.

Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.
Collagen from bovine nasal septum has been used to coat the plates to estimate the levels of serum anti-cII IgG by enzyme-linked immunosorbent assay (ELISA). It has also been used as a component in the emulsified agent to induce arthritis in rats.

Packaging

5 mg in glass bottle
10 mg in poly bottle

Biochem/physiol Actions

Collagen is the structural constituent of the dermis, which provides strength and support to the human skin. Variations in collagen participates in the aging process.

Preparation Note

Collagen Type II is a triple helix composed of three α1(II) strands.
An acid soluble collagen soluble in dilute acetic acid at pH 3.0 (5 mg/ml), yielding an opalescent, colorless solution.
Prepared by a modification of the pepsin extraction procedure of Niyibizi, et al., J. Biol. Chem., 259, 14170 (1984).

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

The protective effects of chronic intermittent hypobaric hypoxia pretreatment against collagen-induced arthritis in rats
Shi M, et al.
Journal of Inflammation, 12(1), 23-23 (2015)
Aging and the skin
Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 133-137 (2010)
Rui Liu et al.
Therapeutic advances in chronic disease, 12, 2040622321991705-2040622321991705 (2021-05-18)
Evidence has demonstrated that non-coding RNAs (ncRNAs) could be delivered efficiently to recipient cells using exosomes as a carrier. Additionally, long ncRNA nuclear enriched abundant transcript 1 (NEAT1) is emerging as a vital regulatory molecule in the progression of rheumatoid
From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
Korganow AS, et al.
Immunity, 10(4), 451-461 (1999)
Aspects of collagen mineralization in hard tissue formation
Wiesmann HP, et al.
International Review of Cytology, 242, 121-156 (2005)

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