Merck
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C8198

Sigma-Aldrich

Anti-Calcitonin Gene Related Peptide antibody produced in rabbit

whole antiserum

Synonym(s):
CGRP Antibody - Anti-Calcitonin Gene Related Peptide antibody produced in rabbit, Cgrp Antibody, Anti-CGRP
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

15 mM sodium azide

species reactivity

rat

packaging

antibody small pack of 25 μL

technique(s)

ELISA: suitable
dot blot: 1:10,000
immunohistochemistry: 1:8,000 using 4% paraformaldehyde perfusion-fixed, frozen sections of rat brain

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

Related Categories

General description

Calcitonin Gene Related Peptide (CGRP), a cyclic peptide, belongs to a small family of peptides encoded by the calcitonin/CGRP gene complex. The calcitonin/CGRP gene complex consists of at least two genes, encoding for two forms of CGRP: -CGRP (CGRP-I) and -CGRP (CGRP-II). CGRP is synthesized and co-localized with calcitonin in the parafollicular C-cells of the thyroid gland and medullary thyroid carcinoma. It is principally considered a neuropeptide widely distributed in the central and peripheral nervous systems.

Specificity

Anti-Calcitonin Gene Related Peptide reacts with CGRP (rat). Cross-reactivity is observed with CGRP (human) and β-CGRP (human).

Immunogen

CGRP-KLH

Application

Anti-Calcitonin Gene Related Peptide antibody produced in rabbit has been used in:
  • dot blot immunoassay
  • fluorescent labeling
  • confocal microscopy
  • immunohistofluorescence
  • epifluorescence imaging

Anti-Calcitonin Gene Related Peptide antibody produced in rabbit was used for immunohistochemistry of trigeminal ganglia cell cultures at a dilution of 1:200 and for immunocytochemistry of mouse lung slices at a dilution of 1:500.

Biochem/physiol Actions

CGRP is thought to act as a neurotransmitter or neuromodulator, particularly in the regulation of autonomic (e.g., cardiovascular, respiratory, gastrointestinal, taste, food intake and sleep) and limbic functions. CGRP is probably involved with substance P in mediating neurogenic inflammation and transmission of pain stimuli via the peripheral nervous system.
Calcitonin Gene Related Peptide is a G protein-coupled receptor that binds receptor-activity-modifying proteins (RAMP)1, -2 and -3. CLR has been implicated in conditions such as obesity, diabetes, osteoporosis, migraine and cardiovascular disease.

Quantity

delipidized

Physical form

Supplied as a liquid containing 0.1% sodium azide as a preservative

Storage and Stability

For continuous use, store 2-8°C. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free"freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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SDS

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