Merck
All Photos(2)

C9301

Sigma-Aldrich

Collagen from chicken sternal cartilage

Type II (Miller), powder, BioReagent, suitable for cell culture

CAS Number:
EC Number:
MDL number:
NACRES:
NA.75

Quality Level

biological source

chicken (Sternal cartilage)

sterility

non-sterile

type

Type II (Miller)

product line

BioReagent

assay

60-80% (biuret)

form

powder

packaging

glass bottle of 100 mg
poly bottle of 25 mg
glass bottle of 5 mg

technique(s)

cell culture | mammalian: suitable

surface coverage

6‑10 μg/cm2

solubility

acetic acid: 0.5-2.0 mg/mL (Dissolve for several hours at 2-8 °C, occasionally swirling.)

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

chicken ... COL2A1(395069)

Related Categories

General description

Collagen is made of three polypeptide chains. Type 2 collagen is ubiquitously present in the hyaline cartilage. It is a homotrimer made of three α1 chains. Type 2 collagen is also predominant in nucleus pulposus of the vertebral disc and vitreous body of the eye. The proteoglycan obtained from the chicken sternal cartilage is similar to type nine collagen structure.
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Application

Collagen from chicken sternal cartilage has been used in enzyme–linked immunosorbent assay (ELISA) , chondrocyte-mediated tissue production in vitro, induction, treatment and assessment of collagenα induced arthritis (CIA) and cell proliferation assay.

Packaging

25 mg in poly bottle
5 mg in glass bottle
100 mg in glass bottle

Other Notes

Major component of articular cartilage.

Preparation Note

Prepared by a modification of the method of Trentham, D.E., et al.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Product Information Sheet

Quotes and Ordering

High-density lipoproteins attenuate high glucose-impaired endothelial cell signaling and functions: potential implications for improved vascular repair in diabetes.
Chen X, et al.
Cardiovascular Diabetology, 16(1), 121-121 (2017)
Blockade of the interleukin?7 receptor inhibits collagen?induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators.
Hartgring S A, et al.
Arthritis and Rheumatism, 62(9), 2716-2725 (2010)
Deletion of either CD55 or CD97 ameliorates arthritis in mouse models.
Hoek R M, et al.
Arthritis and Rheumatism, 62(4), 1036-1042 (2010)
Clinical Impact of Bone and Connective Tissue Markers (2012)
Lipopolysaccharide Increases the Incidence of Collagen?Induced Arthritis in Mice Through Induction of Protease HTRA?1 Expression.
Hou Y, et al.
Arthritis and Rheumatism, 65(11), 2835-2846 (2013)

Articles

Cancer Stem Cells: Targets for Cancer Therapy

Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

Extracellular Matrix Proteins and Tools for Cell Culture Optimization

Extracellular matrix proteins such as laminin, collagen, and fibronectin can be used as cell attachment substrates in cell culture.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service