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CRISPR/Cas9 Products and Services

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Synonym(s):
Synthetic CRISPR, crRNA, tracrRNA, CRISPR, CRISPRs, Cas9, Crispr RNA, Crispr/Cas System
Ari E Friedland et al.
Nature methods, 10(8), 741-743 (2013-07-03)
We report the use of clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease Cas9 to target genomic sequences in the Caenorhabditis elegans germ line using single-guide RNAs that are expressed from a U6 small nuclear RNA promoter. Our results demonstrate
Haoyi Wang et al.
Cell, 153(4), 910-918 (2013-05-07)
Mice carrying mutations in multiple genes are traditionally generated by sequential recombination in embryonic stem cells and/or time-consuming intercrossing of mice with a single mutation. The CRISPR/Cas system has been adapted as an efficient gene-targeting technology with the potential for
Stephen J Pettitt et al.
Nature communications, 9(1), 1849-1849 (2018-05-12)
Although PARP inhibitors (PARPi) target homologous recombination defective tumours, drug resistance frequently emerges, often via poorly understood mechanisms. Here, using genome-wide and high-density CRISPR-Cas9 "tag-mutate-enrich" mutagenesis screens, we identify close to full-length mutant forms of PARP1 that cause in vitro
Hirotaka Ebina et al.
Scientific reports, 3, 2510-2510 (2013-08-27)
Even though highly active anti-retroviral therapy is able to keep HIV-1 replication under control, the virus can lie in a dormant state within the host genome, known as a latent reservoir, and poses a threat to re-emerge at any time.
Marian L Burr et al.
Cancer cell, 36(4), 385-401 (2019-10-01)
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved function of polycomb repressive complex 2 (PRC2) that mediates coordinated transcriptional silencing of the MHC-I antigen processing

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