G0639
Glybenclamide
≥99% (HPLC)
Synonym(s):
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide, Glyburide, N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N′-cyclohexylurea
About This Item
Recommended Products
Assay
≥99% (HPLC)
solubility
ethanol: 2 mg/mL
DMSO: soluble
H2O: insoluble
originator
Roche
storage temp.
2-8°C
SMILES string
COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
InChI
1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
InChI key
ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Gene Information
human ... ABCC8(6833) , KCNH2(3757) , KCNJ1(3758) , KCNJ11(3767)
rat ... Kcnj1(24521)
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Application
- as a positive control oral hypoglycemic drug to study the hypoglycemic effects of Chlorella in streptozotocin-induced diabetic mice
- as a K+ATP channel antagonist in canine with induced acute hypoxia
- as an inhibitor of cystic fibrosis transmembrane conductance regulator (CFTR) channel in fetal distal lung epithelial (FDLE) cells
Biochem/physiol Actions
Features and Benefits
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 4
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Certificates of Analysis (COA)
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