G6013

L-Glutathione reduced

suitable for cell culture, BioReagent, ≥98.0%, powder

• Synonym(s): Glutathione, Reduced, γ-L-Glutamyl-L-cysteinyl-glycine, GSH
• Linear Formula: H₂NCH(CO₂H)CH₂CH₂CONHCH(CH₂SH)CONHCH₂CO₂H
• CAS Number: 70-18-8
• Molecular Weight: 307.32
• Beilstein: 1729812
• EC Number: 200-725-4
• MDL number: MFCD00065939
• PubChem Substance ID: 24895241
• NACRES: NA.26

Properties

• product line: BioReagent
• Quality Level: 300
• Assay: ≥98.0%
• form: powder
• technique(s): cell culture | mammalian: suitable
• color: white
• mp: 192-195 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
• InChI: 1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
• InChI key: RWSXRVCMGQZWBV-WDSKDSINSA-N

Description

Amino Acid Sequence

γ-Glu-Cys-Gly

Application

May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Biochem/physiol Actions

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves