Merck
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G9145

Sigma-Aldrich

[Leu15]-Gastrin I human

≥95% (HPLC)

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Synonym(s):
[Leu15]-HG-17, LHG-17, [15-Leucine]-Gastrin I, human heptadecapeptide, [18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human, [Leu15]-Gastrin I, human, [Leucine15]-Gastrin I heptadecapeptide, [Leucine15]-Little gastrin I
Empirical Formula (Hill Notation):
C98H126N20O31
CAS Number:
Molecular Weight:
2080.16
Beilstein:
5227423
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32

biological source

human

Quality Level

Assay

≥95% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C3CCCN3C(=O)CNC(=O)C4CCC(=O)N4)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(C)C(=O)NC(Cc5ccc(O)cc5)C(=O)NCC(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc8ccccc8)C(N)=O

InChI

1S/C98H126N20O31/c1-49(2)38-68(115-96(147)72(43-55-46-101-60-19-12-10-17-58(55)60)117-98(149)74-20-13-37-118(74)77(122)48-103-86(137)61-25-31-75(120)105-61)93(144)111-66(30-36-82(131)132)92(143)110-65(29-35-81(129)130)91(142)109-64(28-34-80(127)128)90(141)108-63(27-33-79(125)126)89(140)107-62(26-32-78(123)124)88(139)104-51(5)85(136)113-70(41-53-21-23-56(119)24-22-53)87(138)102-47-76(121)106-71(42-54-45-100-59-18-11-9-16-57(54)59)95(146)114-69(39-50(3)4)94(145)116-73(44-83(133)134)97(148)112-67(84(99)135)40-52-14-7-6-8-15-52/h6-12,14-19,21-24,45-46,49-51,61-74,100-101,119H,13,20,25-44,47-48H2,1-5H3,(H2,99,135)(H,102,138)(H,103,137)(H,104,139)(H,105,120)(H,106,121)(H,107,140)(H,108,141)(H,109,142)(H,110,143)(H,111,144)(H,112,148)(H,113,136)(H,114,146)(H,115,147)(H,116,145)(H,117,149)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,133,134)

InChI key

CMVMLPDUAGUTOC-UHFFFAOYSA-N

Gene Information

human ... GAST(2520)

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This Item
G9020A9650I3769
Gastrin I human ≥95% (HPLC), powder

Sigma-Aldrich

G9020

Gastrin I human

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥95% (HPLC)

form

powder

form

powder

form

powder

form

lyophilized powder

technique(s)

cell culture | mammalian: suitable

technique(s)

protein expression: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P01350

UniProt accession no.

P01350

UniProt accession no.

P01019

UniProt accession no.

P05019

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Amino Acid Sequence

Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

General description

GAST gene encodes for the protein [Leu15]-Gastrin I in human. In human chromosome, the gene GAST is localized on 17q21.2. G cells in the stomach antrum produces the precursor of [Leu15]-Gastrin I, progastrin. Progastrin undergoes cleavage and processing to yield gastrin, which is trophic for the entire gastrointestinal epithelium. Gastrin is essential for the growth of the digestive system and stimulates the production of gastric acid by parietal cells. Gastrin exerts its function through G-protein-coupled receptor called the cholecystokinin (CCK) or CCK-B receptor (CCK-BR). Gastrin release is stimulated by food, especially protein diet and is inhibited by very low pH. Atrophic gastritis, a Helicobacter pylori infection and long-term administration of proton pump inhibitors infection may cause overexpression of gastrin. Gastric adenocarcinoma show high levels of gastrin.

Application

Gastrin has been used:
  • as a medium supplement establish enteroid cultures
  • as a supplement to standard Dulbecco′s Modified Eagle Medium (DMEM) culture medium, human minigut medium to establish the growth of crypts.

Biochem/physiol Actions

Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu15 replaces Met15, that is readily oxidized resulting in loss of biological activity.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1-and protease-activated receptor 4-dependent mechanism
Sebert M, et al.
British Journal of Pharmacology, 175(18), 3656-3668 (2018)
Handbook of Biologically Active Peptides, 1219-1226 (2013)
Human fetal-derived enterospheres provide insights on intestinal development and a novel model to study necrotizing enterocolitis (NEC)
Senger S, et al.
Cellular and molecular gastroenterology and hepatology, 5(4), 549-568 (2018)
Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy
Mahe MM, et al.
Journal of Visualized Experiments, (97), e52483-e52483 (2015)
D Chen et al.
Scandinavian journal of gastroenterology, 31(4), 404-410 (1996-04-01)
Gastrin is thought to stimulate growth of the pancreas via gastrin/cholecystokinin (CCK)-B-type receptors. The aim of the present study was to examine the trophic response of the pancreas to exogenous gastrin or to hypergastrinemia of endogenous origin and to hypogastrinemia

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