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H0652

Sigma-Aldrich

Anti-Hepatocyte Growth Factor antibody produced in goat

IgG fraction of antiserum, lyophilized powder

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Synonym(s):
Anti-HGF
MDL number:
NACRES:
NA.41

biological source

goat

Quality Level

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

neutralization: suitable
western blot: suitable

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HGF(3082)

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General description

Hepatocyte Growth Factor (HGF) is a multifunctional, heparin-binding factor that stimulates the proliferation of liver cells. The cellular effects of HGF are mediated by its receptor, c-Met, that leads to significant activation of ERK, Src/FAK, STAT3 and PI3K signaling. Cells of mesenchymal origin express HGF that stimulates the c-Met expression via an autocrine loop. Various functions of the HGF/c-Met signaling include proliferation, cell survival, motility and adhesion and tissue regeneration. Apart from liver, HGF also mediates regeneration of kidney, lung and gastro-intestines. It is also important for maintaining the insulin production and prevents hypoglycemia, self-repair of cartilage, muscle and skin and hematopoiesis. The HGF/c-Met signaling is reported as a promising therapeutic target in prevention of angiogenesis in cancer and maintaining synaptic plasticity in Alzheimer′s disease
Monoclonal Anti-Hepatocyte Growth Factor recognizes human HGF.

Immunogen

recombinant human hepatocyte growth factor.

Application

Anti-Hepatocyte Growth Factor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml is recommended. The antibody is suitable for neutralization reactions. A concentration of 500ng/ml of anti-HGF has been used to neutralize HGF in the conditioned medium of NIH3TS cells. Anti-HGF has been used at a working concentration of 20μg/ml for immunohistochemistry of section of cervical lesions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified by Protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Y Ueoka et al.
British journal of cancer, 82(4), 891-899 (2000-03-25)
Hepatocyte growth factor (HGF) is a multifunctional growth factor which has pleiotrophic biological effects on epithelial cells such as proliferation, motogenesis, invasiveness and morphogenesis. Peritoneal dissemination is critical for the progression of ovarian cancer, and our study revealed that HGF
Francine Walker et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 9(1), 273-284 (2003-01-23)
High prevalence of squamous cervical intraepithelial neoplasia (CIN) linked to oncogenic human papillomavirus (HPV) exits in HIV-infected women. Hepatocyte growth factor (HGF) and its receptor, c-Met, promote cell proliferation and are involved in tumor progression. Nothing is yet known about
Lei Zhuang et al.
Oncology reports, 42(5), 1781-1792 (2019-09-06)
Cardiac fibrosis is a pathological consequence of radiation‑induced fibroblast proliferation and fibroblast‑to‑myofibroblast transition (FMT). Mesenchymal stem cell (MSC) transplantation has been revealed to be an effective treatment strategy to inhibit cardiac fibrosis. We identified a novel MSC‑driven mechanism that inhibited
Nai-Chen Cheng et al.
Frontiers in cell and developmental biology, 8, 558354-558354 (2020-11-17)
Adipose-derived stem cell (ASC) is a valuable source of cell therapy. By stimulating extracellular matrix (ECM) secretion, ASC sheets can be fabricated with enhanced regenerative capabilities. In recent years, human platelet lysate (HPL) provides an attractive alternative to fetal bovine
Shiv Sharma
TheScientificWorldJournal, 10, 457-461 (2010-03-23)
The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays

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