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H3884

Sigma-Aldrich

Hyaluronidase from bovine testes

Type IV-S, lyophilized powder (essentially salt-free), 750-3000 units/mg solid

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Synonym(s):
Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase
CAS Number:
Enzyme Commission number:
EC Number:
MDL number:

biological source

bovine testis

Quality Level

conjugate

conjugate (Glucosaminoglycan)

type

Type IV-S

form

lyophilized powder (essentially salt-free)

specific activity

750-3000 units/mg solid

mol wt

~55 kDa (four subunits of 14 kDa each)

UniProt accession no.

application(s)

diagnostic assay manufacturing

relevant disease(s)

cancer

storage temp.

−20°C

Gene Information

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1 of 4

This Item
H3631H3757H3506
vibrant-m

H3884

Hyaluronidase from bovine testes

vibrant-m

H3631

Hyaluronidase from bovine testes

vibrant-m

H3757

Hyaluronidase from bovine testes

vibrant-m

H3506

Hyaluronidase from bovine testes

biological source

bovine testis

biological source

bovine testis

biological source

bovine testis

biological source

-

Gene Information

cow ... HYAL1(515397), HYAL2(281838)

Gene Information

cow ... HYAL1(515397), HYAL2(281838)

Gene Information

cow ... HYAL1(515397), HYAL2(281838)

Gene Information

-

mol wt

~55 kDa (four subunits of 14 kDa each)

mol wt

~55 kDa (four subunits of 14 kDa each)

mol wt

~55 kDa (four subunits of 14 kDa each)

mol wt

~55 kDa (four subunits of 14 kDa each)

form

lyophilized powder (essentially salt-free)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

UniProt accession no.

Q5E985, Q8SQG8

UniProt accession no.

Q5E985, Q8SQG8

UniProt accession no.

Q5E985, Q8SQG8

UniProt accession no.

Q5E985, Q8SQG8

Biochem/physiol Actions

Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression.
These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.

Unit Definition

One unit will degrade 0.75 μg of the polysaccharide hyaluronic acid per minute at pH 5.35 at 37 ºC (as measured by turbidimetric absorbance (λ: 600nm) when complexed with BSA after 45 minutes).

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Resp. Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Articles

Hepatocytes are epithelial cells found in the liver. They perform important functions, such as helping to detoxify blood, and to synthesize transport proteins, such as lipoprotein, albumin and transferrin. Primary and secondary cultures of hepatocytes are useful for studying the mechanisms of liver regeneration and differentiation.

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Protocols

This procedure may be used for Hyaluronidase products.

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