Merck
All Photos(1)

I3661

Sigma-Aldrich

Insulin-FITC labeled human

recombinant, expressed in yeast, lyophilized powder

EC Number:
NACRES:
NA.83

Quality Level

recombinant

expressed in yeast

form

lyophilized powder
solid

composition

Insulin, ≥75% biuret

extent of labeling

≥1 mol FITC per mol insulin

shipped in

dry ice
dry ice

storage temp.

−20°C
−20°C

General description

Insulin is a polypeptide hormone mainly secreted from pancreas when glucose level changes in the plasma. It is an anabolic hormone and enhances the generation of storage substances, for instance glycogen, fat and protein. It also induces glucose uptake by peripheral tissues, thereby controlling glucose levels in the plasma. Its main sites of action are liver, adipose tissue and muscle.

Application

Insulin-FITC labeled human has been used in primary endothelial cells from human adipose tissue microvasculature (HAMEC) to study insulin transcytosis.

Physical form

Lyophilized powder containing sodium phosphate buffer salts

Storage Class Code

13 - Non Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Espinal J
Understanding Insulin Action: Principles and Molecular Mechanisms (1989)
Cristina C Clement et al.
Scientific reports, 8(1), 11253-11253 (2018-07-28)
Transport of tissue-derived lymphatic fluid and clearance by draining lymph nodes are pivotal for maintenance of fluid homeostasis in the body and for immune-surveillance of the self- and non-self-proteomes. Yet a quantitative analysis of nodal filtration of the tissue-derived proteome
Aaron L Glieberman et al.
Lab on a chip, 19(18), 2993-3010 (2019-08-30)
Pancreatic β cell function is compromised in diabetes and is typically assessed by measuring insulin secretion during glucose stimulation. Traditionally, measurement of glucose-stimulated insulin secretion involves manual liquid handling, heterogeneous stimulus delivery, and enzyme-linked immunosorbent assays that require large numbers
Hanwoong Woo et al.
Molecular brain, 11(1), 37-37 (2018-07-05)
Chronic stress is a psychologically significant factor that impairs learning and memory in the hippocampus. Insulin signaling is important for the development and cognitive function of the hippocampus. However, the relation between chronic stress and insulin signaling at the molecular
Nicolas J Pillon et al.
American journal of physiology. Endocrinology and metabolism, 309(1), E35-E44 (2015-05-07)
Obesity is associated with inflammation and immune cell recruitment to adipose tissue, muscle and intima of atherosclerotic blood vessels. Obesity and hyperlipidemia are also associated with tissue insulin resistance and can compromise insulin delivery to muscle. The muscle/fat microvascular endothelium

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service