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M2420

Sigma-Aldrich

Monoclonal Anti-Monocyte Chemotactic Protein-1 antibody produced in mouse

clone 24822, purified immunoglobulin, lyophilized powder

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Synonym(s):
Anti-CCL2, Anti-MCP-1
MDL number:
MFCD00282367

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

24822, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

neutralization: suitable
western blot: suitable

isotype

IgG1

UniProt accession no.

P13500

storage temp.

−20°C

Gene Information

human ... CCL2(6347)

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purified immunoglobulin

clone

24822, monoclonal

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species reactivity

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species reactivity

human

General description

Monocyte Chemotactic Protein-1 (MCP-1) is a chemotactic factor that belongs to CC chemokine family and can attract basophils and monocytes but not eosinophils or neutrophils. It is produced in keratinocytes, fibroblasts, hepatoma cells and Type II pneumocytes in response to IL-1. It has a crucial role in recruiting immune cells to the site of antigens as well as behaves as an inflammatory mediator which stimulates the directional migration of T cells and monocytes. Monoclonal anti-Monocyte Chemotactic Protein-1 antibody is suitable for neutralization, in which it will not neutralize the activity of recombinant human MIP-1α, recombinant mouse MIP-1α or recombinant human RANTES. Mouse anti-Monocyte Chemotactic Protein-1 antibody reacts specifically with human MCP-1/CCL2.

Specificity

The antibody will neutralize the biological activity of recombinant human MCP-1.This antibody does not exhibit cross-reactivity with recombinant human RANTES, recombinant human MIP-1α, or recombinant mouse MIP-1α..

Immunogen

recombinant human MCP-1/CCL2 expressed in E. coli.

Application

Monoclonal anti-Monocyte Chemotactic Protein-1 antibody can be used in western blotting.

Physical form

Lyophilized from a 0.2 μm solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using protein A.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Haijun Zhang et al.
The journal of pain : official journal of the American Pain Society, 14(10), 1031-1044 (2013-06-04)
The use of paclitaxel (Taxol), a microtubule stabilizer, for cancer treatment is often limited by its associated peripheral neuropathy (chemotherapy-induced peripheral neuropathy [CIPN]), which predominantly results in sensory dysfunction, including chronic pain. Here we show that paclitaxel CIPN was associated
D D Taub et al.
The Journal of clinical investigation, 95(3), 1370-1376 (1995-03-01)
Monocyte chemotactic protein (MCP)-1, -2, and -3 all have been shown to induce monocyte/macrophage migration in vitro and MCP-1, also known as MCAF, chemoattracts basophils and mast cells. We report here that natural MCP-1 as well as synthetic preparations of
Y Furutani et al.
Biochemical and biophysical research communications, 159(1), 249-255 (1989-02-28)
cDNA clones having a nucleotide sequence encoding a human monocyte chemotactic and activating factor (MCAF) were isolated and sequenced. The amino acid sequence deduced from the nucleotide sequence reveals the primary structure of the MCAF precursor to be composed of
Kenichiro Kobayashi et al.
Hepatology communications, 2(3), 230-236 (2018-03-07)
Liver fibrosis is a common complication associated with transient myeloproliferative disorder (TMD) in Down syndrome (DS). The exact molecular pathogenesis that regulates disease progression is largely unknown. We recently found serum and/or urinary monocyte chemoattractant protein-1 (MCP-1) as a novel

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