Merck
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M8439

SAFC

L-Methionine

Synonym(s):
(S)-2-Amino-4-(methylmercapto)butyric acid, L-2-Amino-4-(methylthio)butanoic acid
Linear Formula:
CH3SCH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
149.21
Beilstein:
1722294
EC Number:
MDL number:
eCl@ss:
32160406
NACRES:
NA.26

biological source

non-animal source

Quality Level

Assay

≥99%

form

powder

manufacturer/tradename

Ajinomoto

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, heavy metals, trace metals, residual solvents, tested

mp

284 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

suitability

suitable for manufacturing use

application(s)

pharmaceutical (small molecule)

foreign activity

cytotoxicity, tested

SMILES string

CSCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChI key

FFEARJCKVFRZRR-BYPYZUCNSA-N

Gene Information

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This Item
M5308PHR12411411504
L-Methionine

SAFC

M8439

L-Methionine

L-Methionine from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0%

Sigma-Aldrich

M5308

L-Methionine

L-Methionine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1241

L-Methionine

L-Methionine United States Pharmacopeia (USP) Reference Standard

USP

1411504

L-Methionine

form

powder

form

powder

form

-

form

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

impurities

endotoxin, heavy metals, trace metals, residual solvents, tested

impurities

endotoxin, tested

impurities

-

impurities

-

mp

284 °C (dec.) (lit.)

mp

284 °C (dec.) (lit.)

mp

284 °C (dec.) (lit.)

mp

284 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

solubility

H2O: 25 mg/mL

solubility

-

solubility

-

General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Application

L-Methionine is an essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Methionine European Pharmacopoeia (EP) Reference Standard

M0960000

Methionine

Geneviève Deblois et al.
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Tumor progression upon treatment arises from preexisting resistant cancer cells and/or adaptation of persister cancer cells committing to an expansion phase. Here, we show that evasion from viral mimicry response allows the growth of taxane-resistant triple-negative breast cancer (TNBC). This
Ronald O Ball et al.
The Journal of nutrition, 136(6 Suppl), 1682S-1693S (2006-05-17)
Sulfur amino acid metabolism has been receiving increased attention because of the link to chronic diseases such as cardiovascular disease, Alzheimer's disease, and diabetes. In addition, the role of cysteine and optimal intakes for physiological substrates such as glutathione are
B Almé et al.
Journal of lipid research, 18(3), 339-362 (1977-05-01)
A method is described for quantitative analysis of bile acids in urine. Urine is acidified and bile acids are extracted on an Amberlite XAD-2 column. Bile salts are converted to acids on an Amberlyst A-15 column and are separated into
Eline van Meel et al.
BMC medical genetics, 14, 106-106 (2013-10-10)
Methionyl-tRNA synthetase (MARS) catalyzes the ligation of methionine to its cognate transfer RNA and therefore plays an essential role in protein biosynthesis. We used exome sequencing, aminoacylation assays, homology modeling, and immuno-isolation of transfected MARS to identify and characterize mutations
Andor W J M Glaudemans et al.
European journal of nuclear medicine and molecular imaging, 40(4), 615-635 (2012-12-13)
(11)C-methionine (MET) is the most popular amino acid tracer used in PET imaging of brain tumours. Because of its characteristics, MET PET provides a high detection rate of brain tumours and good lesion delineation. This review focuses on the role

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