N1905

Neurotrophin-3 human

Name: Neurotrophin-3 human
Brand: SIGMA
Price: 8627 MXP

recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, >97% (SDS-PAGE)

Synonym(s):

HDNF, NTF3, NT-3

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N1905-5UG

MXP 8,627.00

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About This Item

MDL number:

MFCD00212404

UNSPSC Code:

12352202

NACRES:

NA.32

Key Documents

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biological source

human

Quality Level

200

recombinant

expressed in baculovirus infected Sf21 cells

Assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

1-40 ng/mL EC₅₀

packaging

pkg of 5 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P20783

storage temp.

−20°C

Gene Information

human ... NTF3(4908)

Related Categories

Cell Culture & Analysis

Cell Culture Supplements & Reagents

Growth Factors and Cytokines

Molecular Biology & Functional Genomics

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This Item	SRP3128	N5415	G1777
Sigma-Aldrich N1905 Neurotrophin-3 human	Sigma-Aldrich SRP3128 NT-3 human	Sigma-Aldrich N5415 Nerve Growth Factor-ß human	Sigma-Aldrich G1777 Glial Cell Line-derived Neurotrophic Factor human
recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in E. coli	recombinant expressed in HEK 293 cells	recombinant expressed in E. coli
biological source human	biological source human	biological source human	biological source human
assay >97% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay ≥98% (SDS-PAGE)
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
Quality Level 200	Quality Level -	Quality Level 200	Quality Level 200
form lyophilized powder	form lyophilized	form lyophilized powder	form lyophilized powder

General description

NTF3 (neurotrophin 3) is a neurotrophic factor belonging to the NGF (nerve growth factor) family.[1] This protein is made up of 257 amino acids, with a prepro region of 138 amino acids and the mature sequence of 119 residues.[2]

Application

Neurotrophin-3 human has been used in the magnetic sorting of oligodendrocyte progenitor cells.[3]

Biochem/physiol Actions

Neurotrophin-3 (13.6 kDa or 27.2 kDa dimer) is a member of the neurotrophin family. It has identical amino acid sequence in human, mouse, and pig with full cross-reactivities. NT-3 is important in development and maintenance of neuronal populations and promotes differentiation of neural crest derived sensory and sympathetic neurons. It is critical for proprioceptive 1a afferent neurons, which relay information from peripheral muscle spindles to motoneurons, sending projections to spinocerebellar neurons. NT-3 is also critical in the superior cervical and nodose ganglia.

Physical form

Lyophilized from a 0.2 m filtered solution in phosphate buffered saline (PBS) containing 50 μg of bovine serum albumin (BSA) per 1 μg of cytokine.

Analysis Note

The biological activity is measured in a cell proliferation assay using a TrkB-transfected cell line BaF-TrkB-BD.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Defective glial maturation in vanishing white matter disease

Bugiani M, et al.

Journal of Neuropathology and Experimental Neurology, 70(1), 69-82 (2011)

Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis

Louie E, et al.

Oncogene, 32(35), 4064-4064 (2013)

Cloning and expression of a cDNA encoding a novel human neurotrophic factor.

Kaisho Y et al

Febs Letters, 266(1-2), 187-191 (1990)

Neurotrophin 3 is a mitogen for cultured neural crest cells.

Kalcheim C et al

Proceedings of the National Academy of Sciences of the USA, 89(5), 1661-1665 (1992)

Linkage of the gene for the triple A syndrome to chromosome 12q13 near the type II keratin gene cluster

Weber A, et al.

Human Molecular Genetics, 5(12), 2061-2066 (1996)

View All Related Papers

Articles

Derivation of Functional Oligodendrocyte Progenitor Cells (OPCs) from Human Neural Stem Cell Lines

Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.

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