Merck
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N5751

Sigma-Aldrich

Nω-Nitro-L-arginine methyl ester hydrochloride

≥98% (TLC), powder

Synonym(s):
L-NAME hydrochloride
Empirical Formula (Hill Notation):
C7H15N5O4 · HCl
CAS Number:
Molecular Weight:
269.69
Beilstein:
3744166
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

biological source

synthetic

assay

≥98% (TLC)

form

powder

color

white to off-white

mp

132 °C

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O

InChI

1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1

InChI key

QBNXAGZYLSRPJK-JEDNCBNOSA-N

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Application

Nω-Nitro-L-arginine methyl ester hydrochloride has been used:
  • to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons
  • to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin
  • to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells
  • to study its effect on the levels of arginine vasopressin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat

Packaging

250 mg in poly bottle
1, 5, 10, 25 g in poly bottle

Biochem/physiol Actions

An analog of arginine that inhibits NO production. It has multiple effects on the vascular system. Inhibits relaxation induced by acetylcholine and induces an increase in arterial blood pressure. Abolishes lecithinized superoxide dismutase induced vasodilation when used to pretreat aortic ring preparations of mice. Induces leukocyte adhesion and increases microvascular fluid and protein fluxes and permeability. It has also been used in many studies of learning and memory.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

More Documents

Quotes and Ordering

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