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P4543

Sigma-Aldrich

Valproic acid sodium salt

98%

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Synonym(s):
2-propylpentanoic acid sodium, Sodium 2-propylpentanoate, Sodium valproate
Empirical Formula (Hill Notation):
C8H15NaO2
CAS Number:
Molecular Weight:
166.19
EC Number:
MDL number:
eCl@ss:
42020819
PubChem Substance ID:

Quality Level

Assay

98%

form

powder

solubility

H2O: 50 mg/mL

originator

Abbott

SMILES string

[Na+].CCCC(CCC)C([O-])=O

InChI

1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1

InChI key

AEQFSUDEHCCHBT-UHFFFAOYSA-M

Gene Information

human ... ALDH5A1(7915)

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1 of 4

This Item
BP45271642S0930000
Sodium valproate British Pharmacopoeia (BP) Reference Standard

BP452

Sodium valproate

Sodium valproate European Pharmacopoeia (EP) Reference Standard

S0930000

Sodium valproate

form

powder

form

-

form

powder

form

-

solubility

H2O: 50 mg/mL

solubility

-

solubility

water: soluble 50 mg/mL at 25 °C

solubility

-

originator

Abbott

originator

-

originator

-

originator

-

Gene Information

human ... ALDH5A1(7915)

Gene Information

human ... ALDH5A1(7915)

Gene Information

-

Gene Information

human ... ALDH5A1(7915)

Application

Valproic acid sodium salt has been used:
  • in resazurin viability assay
  • to systematically study its effects of clinical doses on brain volume and offspring behavior
  • to study its effect on atherosclerotic lesion size

Biochem/physiol Actions

Valproic acid is an anticonvulsant and mood-stabilizing drug. It is used to treat epilepsy and bipolar disorder. Valproic acid helps to repress the Warburg effect and the development of tumor in neuroblastoma.
Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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USP

USP

1224201

Divalproex sodium

Derek Daigle et al.
Journal of virology, 85(11), 5628-5643 (2011-03-18)
Diverse stimuli reactivate the Epstein-Barr virus (EBV) lytic cycle in Burkitt lymphoma (BL) cells. In HH514-16 BL cells, two histone deacetylase (HDAC) inhibitors, sodium butyrate (NaB) and trichostatin A (TSA), and the DNA methyltransferase inhibitor azacytidine (AzaCdR) promote lytic reactivation.
Glucosamine-supplementation promotes endoplasmic reticulum stress, hepatic steatosis and accelerated atherogenesis in apoE-/- mice
Beriault D R, et al.
Atherosclerosis, 219(1), 134-140 (2011)
Erik Taubøll et al.
Epilepsia, 50(8), 1868-1874 (2009-06-06)
Recent animal studies have indicated possible reproductive endocrine effects of levetiracetam (LEV). The aim of the present study was to investigate possible reproductive endocrine effects of LEV compared to valproate (VPA) using human ovarian follicular cells. Cell cultures of human
Dose-dependent memory effects and cerebral volume changes after in utero exposure to valproate in the rat
Frisch C H, et al.
Epilepsia, 50(6), 1432-1441 (2009)
Valproic acid suppresses Warburg effect and tumor progression in neuroblastoma
Fang E, et al.
Biochemical and biophysical research communications (2018)

Articles

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

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