P6126

(R)-(−)-Phenylephrine hydrochloride

powder

• Synonym(s): (R)-(−)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride, (R)-(−)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride
• Linear Formula: HOC₆H₄CH(CH₂NHCH₃)OH·HCl
• CAS Number: 61-76-7
• Molecular Weight: 203.67
• Beilstein: 4158948
• EC Number: 200-517-3
• MDL number: MFCD00012605
• PubChem Substance ID: 57654535
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 200
• mp: 143-145 °C (lit.)
• originator: Johnson & Johnson
• SMILES string: OC1=CC([C@H](CNC)O)=CC=C1.Cl
• InChI: 1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
• InChI key: OCYSGIYOVXAGKQ-FVGYRXGTSA-N
• Gene Information: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Description

General description

(R)-(-)-Phenylephrine hydrochloride is an adrenergic agent, which functions as a β-receptor sympathomimetic drug.

Application

(R)-(-)-Phenylephrine hydrochloride has been used:

• in the preparation and culturing of cardiocytes and fibroblasts
• to stimulate myocardial strips to measure slice contraction
• in primary cardiomyocyte culture to show the effect of Kruppel-like factors (KLF) on cardiac hypertrophy in vivo
• to evaluate the pharmacological response of embryonic stem cell (ESC)-derived cardiomyocytes
• to pharmacologically rescue GATA (erythroid transcription factor) binding protein 3 (GATA3) null embryo from early embryonic lethality

Biochem/physiol Actions

α₁-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 - H317
• Precautionary Statements: P261 - P264 - P270 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves