P8783

Sigma-Aldrich

Progesterone

powder, BioReagent, suitable for cell culture

Synonym(s):
4-Pregnene-3,20-dione
Empirical Formula (Hill Notation):
C21H30O2
CAS Number:
Molecular Weight:
314.46
Beilstein/REAXYS Number:
1915950
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

biological source

synthetic (organic)

description

synthesized from materials derived from plant source

product line

BioReagent

assay

≥99%

form

powder

potency

0.1-20 ng/mL

application(s)

cell culture | mammalian: suitable

mp

128-132 °C (lit.)

solubility

absolute ethanol: 1 mg/mL

storage temp.

room temp

SMILES string

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

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General description

Progesterone is a steroid hormone secreted by the ovaries.

Application

Progesterone has been used:
  • as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture
  • to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model
  • as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Packaging

1, 5, 25 g in glass bottle

Biochem/physiol Actions

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.
Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Other Notes

Steroid hormone produced by the corpus luteum.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitution

To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.

pictograms

Health hazard

signalword

Danger

hazcat

Carc. 2 - Lact. - Repr. 1A

storage_class_code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Germany

WGK 3

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Efficacy of progesterone following a moderate unilateral cortical contusion injury
Gilmer LK, et al.
Journal of Neurotrauma, 25(6), 593-602 (2008)
Peroxisome proliferator-activated receptor-? activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents
A.K.G.Kadegowda, et al.
Journal of Dairy Science, 92, 276-4289 (2009)
Clinical Reproductive Medicine and Surgery, 84(7), 17-17 (2007)
Neonatal progesterone programs adult uterine responses to progesterone and susceptibility to uterine dysfunction
Dhakal P, et al.
Endocrinology, 156(10), 3791-3803 (2015)
Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study.
da Fonseca EB, et al.
American Journal of Obstetrics and Gynecology, 838, 419-424 (2003)

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