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SBPVR4

Sigma-Aldrich

SB PREDIVEZ Reagent Kit for BCRP

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recombinant

expressed in human cells

form

liquid

shipped in

dry ice

storage temp.

−70°C

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SBPVR1SBPE13SBPE03
storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

recombinant

expressed in human cells

recombinant

expressed in human cells

recombinant

expressed in insect cells

recombinant

expressed in insect cells

form

liquid

form

liquid

form

liquid

form

-

General description

SOLVO Biotechnology offers ready-to-use assay kits for efflux and uptake transporters. SOLVO′s PREDIVEZ Vesicular Transport Assay Kits are suitable for efflux transporter inhibition studies. The kits are designed to test the inhibitory effect of one or more test compounds on the vesicular transport of a probe substrate. In most cases a fluorescent probe substrate is included. Kits contain all reagents and solutions necessary to conduct the drug-transporter interaction assay of need.

Application

PREDIVEZ vesicular transport reagent Kit may be used for assessing human ATP binding cassette subfamily B member 1 (ABCB1) function and multidrug resistance-associated protein 2 (MRP2) efflux transporter function.
The PREDIVEZ Vesicular Transport Kit is a simple and powerful tool to investigate drug transporter interactions. It provides information on any interaction between the ABC transporter and the drug candidate that would affect the transport of the fluorescent or radiolabeled or cold.

PREDIVEZ vesicular transport kits contains buffers, probe substrate, and reference inhibitors needed to run vesicular transport assays (sufficient for 300 wells/kit –equivalent to existing 9-cpd PV kits). Assay protocol, calculation template, and example data file available on SOLVO website.

Transport membranes and control membranes are sold separately. This PREDIVEZ vesicular transport kit requires the transporter membranes and corresponding control membrane below:

SSB-BCRP-M-VT BCRP human membrane vesicles part number SBVT09-1EA and corresponding control membrane SB-M-CTRL part number SBCT02-1EA

SB-BCRP-HEK293-VT BCRP human membrane vesicles part number SBVT17-1EA and corresponding control membrane SB-HEK293-Mock-CTRL part number SBCT06-1EA

Legal Information

PREDIVEZ is a trademark of Solvo Biotechnology

Pictograms

CorrosionExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Met. Corr. 1 - Skin Sens. 1

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

188.6 °F

Flash Point(C)

87 °C


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ABCB1 transports Seliciclib (R-Roscovitine), a cyclin-dependent kinase inhibitor
Rajnai Z, et al.
Drug Metabolism and Disposition, dmd-110 (2010)
Impact of probe compound in MRP2 vesicular transport assays
Kidron H , et al.
European Journal of Pharmaceutical Sciences, 46(1-2), 100-105 (2012)

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