Merck
  • SML0499
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SML0499

Sigma-Aldrich

NCTT-956

≥97% (NMR)

Synonym(s):
N-[(8-Hydroxy-5-nitro-7-quinolinyl)-2-thienylmethyl]-propanamide
Empirical Formula (Hill Notation):
C17H15N3O4S
CAS Number:
Molecular Weight:
357.38
MDL number:
PubChem Substance ID:

Quality Level

Assay

≥97% (NMR)

form

powder

color

light orange to dark orange

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

CCC(=O)NC(c1cccs1)c2cc([N+]([O-])=O)c3cccnc3c2O

InChI

1S/C17H15N3O4S/c1-2-14(21)19-15(13-6-4-8-25-13)11-9-12(20(23)24)10-5-3-7-18-16(10)17(11)22/h3-9,15,22H,2H2,1H3,(H,19,21)

InChI key

DEXNORPUTBBNSC-UHFFFAOYSA-N

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NCTT-956 ≥97% (NMR)

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NCT-503 ≥98% (HPLC)

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SML1659

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NCT-501 ≥98% (HPLC)

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SML2089

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CCT137690 ≥98% (HPLC)

Sigma-Aldrich

SML1237

CCT137690

assay

≥97% (NMR)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

light orange to dark orange

color

white to beige

color

white to beige

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

Biochem/physiol Actions

NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC50 of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. Specific inhibition of 12-LO by NCTT-956 in platelets blocks PKC activation, aggregation, granule secretion and αIIbB3 activation.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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