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SML0771

Sigma-Aldrich

LG100754

≥98% (HPLC)

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Synonym(s):
(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-2-naphthalenyl)-2,4,6-Octatrienoic acid
Empirical Formula (Hill Notation):
C26H36O3
CAS Number:
Molecular Weight:
396.56
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C26H36O3/c1-8-14-29-23-17-22-21(25(4,5)12-13-26(22,6)7)16-20(23)19(3)11-9-10-18(2)15-24(27)28/h9-11,15-17H,8,12-14H2,1-7H3,(H,27,28)/b10-9+,18-15+,19-11-

InChI key

HNODNXQAYXJFMQ-LQUSFLDPSA-N

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This Item
SML2015SML1950N8164
Sigma-Aldrich

Sigma-Aldrich

SML0771

LG100754

MM11253 ≥98% (HPLC)

Sigma-Aldrich

SML2015

MM11253

UVI3003 ≥98% (HPLC)

Sigma-Aldrich

SML1950

UVI3003

NSC727447 ≥98% (HPLC)

Sigma-Aldrich

N8164

NSC727447

form

powder

form

powder

form

powder

form

solid

color

white to beige

color

white to beige

color

white to beige

color

-

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

room temp

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

Biochem/physiol Actions

LG100754 is a unique RXR ligand that acts as an antagonist against RXR homodimers, but is a strong agonist for RXR:PPARα and RXR:PPARγ heterodimers. The compound does not have agonist activities for other RXR heterodimers containing LXR or GAR/FXR receptors. LG100754 initiates adipocyte differentiation, inhibits TNFα-induced insulin receptor hypophosphorylation and improves insulin resistance in db/db mice.

Features and Benefits

This compound is featured on the InsR, Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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705578-5MG-PW

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Articles

We offers many products related to InsR for your research needs.

Peroxisome proliferator activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors.

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