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SML1674

Sigma-Aldrich

UPCDC30245

≥98% (HPLC)

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Synonym(s):
1-(3-(5-Fluoro-1H-indol-2-yl)phenyl)-N-(2-(4-isopropylpiperazin-1-yl)ethyl)piperidin-4-amine
Empirical Formula (Hill Notation):
C28H38FN5
CAS Number:
Molecular Weight:
463.63
PubChem Substance ID:

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 30 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC1=CC=C(NC(C2=CC=CC(N3CCC(NCCN4CCN(C(C)C)CC4)CC3)=C2)=C5)C5=C1

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This Item
SML2472SML0662SML2769
UPCDC30245 ≥98% (HPLC)

Sigma-Aldrich

SML1674

UPCDC30245

UPGL00004 ≥98% (HPLC)

Sigma-Aldrich

SML2472

UPGL00004

UNC1215 ≥98% (HPLC)

Sigma-Aldrich

SML0662

UNC1215

ASS234 ≥98% (HPLC)

Sigma-Aldrich

SML2769

ASS234

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to pink

color

white to beige

color

white to beige

solubility

DMSO: 30 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

Biochem/physiol Actions

UPCDC30245 is an allosteric inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). p97 is an integral component of the ubiquitin fusion degradation (UFD) pathway. It plays a role in degradation of misfolded proteins, Golgi membrane reassembly, membrane transport, myofibril assembly, autophagosome maturation, and cell division, and is overexpressed in many tumor types. UPCDC30245 has an IC50 value of 27 nM, and has been shown to bind at the junction between the D1 and D2 domains of p97. UPCDC30245 has been used in cryo-ECM to show how such inhibitor binding prevents the confomational changes necessary for p97 function.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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