Merck
  • T2501
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T2501

Sigma-Aldrich

L-Thyroxine sodium salt pentahydrate

≥98% (HPLC), powder

Synonym(s):
3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt, Sodium levothyroxine, T4
Linear Formula:
HOC6H2I2OC6H2I2CH2CH(NH2)COONa · 5H2O
CAS Number:
Molecular Weight:
888.93
Beilstein:
5721845
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32

biological source

synthetic (organic)

Quality Level

sterility

non-sterile

Assay

≥98% (HPLC)

form

powder

mp

207-210 (dec.) (lit.)

solubility

4 M NH4OH in methanol: 50 mg/mL, clear to hazy, colorless to yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O

InChI

1S/C15H11I4NO4.Na.5H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;;;;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;5*1H2/q;+1;;;;;/p-1/t12-;;;;;;/m0....../s1

InChI key

JMHCCAYJTTWMCX-QWPJCUCISA-M

Gene Information

mouse ... Cnr2(12802)
rat ... Cnr1(25248)

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T0397T5516T6397
biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic

sterility

non-sterile

sterility

γ-irradiated

sterility

γ-irradiated

sterility

-

assay

≥98% (HPLC)

assay

≥98%

assay

≥90% (HPLC)

assay

≥95%

form

powder

form

powder

form

powder

form

powder

mp

207-210 (dec.) (lit.)

mp

207-210 (dec.) (lit.)

mp

-

mp

-

solubility

4 M NH4OH in methanol: 50 mg/mL, clear to hazy, colorless to yellow

solubility

cell culture medium: 0.1 mg/mL, H2O: soluble

solubility

-

solubility

ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow

Biochem/physiol Actions

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Preparation Note

L-Thyroxine sodium salt pentahydrate dissolves in 4 N NH4OH in methanol at 50 mg/ml to yield a clear to hazy, colorless to yellow solution.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

STOT RE 1

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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