Merck
  • T5443
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T5443

Sigma-Aldrich

Tyrphostin AG 825

≥92.5%

Synonym(s):
5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide, Tyrphostin C15
Empirical Formula (Hill Notation):
C19H15N3O3S2
CAS Number:
Molecular Weight:
397.47
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥92.5%

form

powder

solubility

DMSO: soluble
methanol: soluble

storage temp.

−20°C

SMILES string

COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O

InChI

1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+

InChI key

KXDONFLNGBQLTN-WUXMJOGZSA-N

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Tyrphostin AG 825 ≥92.5%

Sigma-Aldrich

T5443

Tyrphostin AG 825

Tyrphostin 51 ≥98%

Sigma-Aldrich

T7665

Tyrphostin 51

Tyrphostin 1 ≥98%

Sigma-Aldrich

T7040

Tyrphostin 1

Tyrphostin AG 1478 ≥98%

Sigma-Aldrich

T4182

Tyrphostin AG 1478

assay

≥92.5%

assay

≥98%

assay

≥98%

assay

≥98%

form

powder

form

powder

form

solid

form

solid

solubility

DMSO: soluble, methanol: soluble

solubility

DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red

solubility

chloroform: soluble 50 mg/mL, clear, light yellow, DMSO: soluble

solubility

0.1 M HCl: soluble <0.4 mg/mL, DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless, ethanol: soluble 10 mg/mL, methylene chloride: soluble 10 mg/mL, 0.1 M NaOH: insoluble, 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

Application

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells1.

Biochem/physiol Actions

Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells2.
EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Tyrphostin AG 825 is soluble in DMSO and methanol.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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