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Salicylic acid

United States Pharmacopeia (USP) Reference Standard

2-Hydroxybenzoic acid
Linear Formula:
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:


pharmaceutical primary standard

vapor density

4.8 (vs air)

vapor pressure

1 mmHg ( 114 °C)




211 °C (lit.)


158-161 °C (lit.)


alcohol: freely soluble
benzene: slightly soluble
boiling water: soluble
chloroform: sparingly soluble
ether: freely soluble
toluene: slightly soluble
water: slightly soluble


1.44 g/cm3 at 20 °C


pharmaceutical (small molecule)



SMILES string




InChI key


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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.
Sales restrictions may apply.

Signal Word


Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2

Storage Class Code

13 - Non Combustible Solids



Flash Point(F)

314.6 °F - closed cup

Flash Point(C)

157 °C - closed cup

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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Jyoti Shah
Current opinion in plant biology, 6(4), 365-371 (2003-07-23)
Salicylic acid is an important signal molecule in plant defense. In the past two years, significant progress has been made in understanding the mechanism of salicylic-acid biosynthesis and signaling in plants. A pathway similar to that found in some bacteria
Jon Lucas Boatwright et al.
Molecular plant pathology, 14(6), 623-634 (2013-04-30)
Salicylic acid (SA) acts as a signalling molecule in plant defence against biotrophic and hemibiotrophic phytopathogens. The biosynthesis of SA on pathogen detection is essential for local and systemic acquired resistance, as well as the accumulation of pathogenesis-related (PR) proteins.
Mariana Rivas-San Vicente et al.
Journal of experimental botany, 62(10), 3321-3338 (2011-03-02)
In recent years salicylic acid (SA) has been the focus of intensive research due to its function as an endogenous signal mediating local and systemic plant defence responses against pathogens. It has also been found that SA plays a role
Gary Loake et al.
Current opinion in plant biology, 10(5), 466-472 (2007-10-02)
Salicylic acid (SA) is synthesised by plants in response to challenge by a diverse range of phytopathogens and is essential to the establishment of both local and systemic-acquired resistance (SAR). SA application induces accumulation of pathogenesis-related (PR) proteins. Mutations leading
A Corina Vlot et al.
Annual review of phytopathology, 47, 177-206 (2009-04-30)
For more than 200 years, the plant hormone salicylic acid (SA) has been studied for its medicinal use in humans. However, its extensive signaling role in plants, particularly in defense against pathogens, has only become evident during the past 20


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