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Solid Formulation: Excipients Used in Pharmaceutical Dosage Forms

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Solid dose formulations are one of the most established dosage forms in pharmaceuticals, and yet the path to market can still be blocked by critical obstacles such as active pharmaceutical ingredient (API) stability, release kinetics, and bioavailability limitations.

Our high-quality pharmaceutical raw materials and functionalized excipients form a comprehensive portfolio that addresses all your most pressing challenges in solid formulation manufacturing, with products that include:

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PARTECK® FUNCTIONAL EXCIPIENTS: FOR YOUR SOLID FORMULATION DEVELOPMENT

When you design a solid dosage formulation, there are many factors to consider: the active pharmaceutical ingredient (API), bioavailability enhancement, release kinetics, specific dosage, packaging, shelf life, and more. Excipients are the backbone of a formulation and affect final formulation properties such as processability, stability and performance. Therefore, it is important to identify an excipient that has the correct functionality and is of high quality.

Our Parteck® functional excipients were designed with these formulator’s challenges in mind and have additional functionalities beyond standard excipients. These excipients are particle optimized and feature unique particle properties tailored for tableting processes, for specific drug delivery technologies, or for solubility enhancement. Thus, our Parteck® functional excipients ensure excellent performance in formulation development and manufacturing. Backed by the Emprove® Program with its stringent quality control, as well as regulatory support and documentation, Parteck® excipients help to speed up your approval processes.

EXPLORE HOW YOU CAN IMPROVE PRODUCTIVITY AND PERFORMANCE

Rows of pink tablets representing a manufacturing environment.

Tablet Formulation

A comprehensive range of functional excipients, facilitating high tablet hardness at low compression forces, short disintegration times as well as high and low API dosages, targeting:

  • Direct compression
  • Granulation
  • Tablet coatings
Purple tablet releasing the active ingredient represented by pink circles.

Solid Dose Drug Delivery

Particle-optimized excipients targeted at different administration routes with the aim to support your desired release kinetics in:

  • Oral sustained release formulations
  • Orally disintegrating tablets (ODT)
  • Dry powder inhalation
Dissolving tablet representing increased dissolution rates and enhanced solubility of the active ingredient.

Solubility Enhancement

Innovative excipients supporting a variety of solubility enhancement approaches to improve API solubility through formulation including:

  • Hot melt extrusion
  • Spray drying
  • Dissolution enhancers
  • Inorganic drug carriers
Solid Dosage Forms that are in the process of being 3D printed.

3D Printing

Specialized excipients for additive manufacturing targeting specifically the pharmaceutical industry with a focus on melt-based 3D printing technologies such as:

  • Melt-drop deposition
Schematic image of a continuous manufacturing process.

Continuous Manufacturing

Portfolio of excipients optimized for excellent performance in Continuous Manufacturing:

  • Parteck® LM self-lubricating filler/binder
  • Parteck® excipient range designed for direct compression and dry granulation
  • Parteck® M mannitol suitable for twin screw granulation
Abstract image representing particle homogenization.

Particle Homogenization

Platform technology based on mesoporous silica to improve formulation efficiency and de-risk solid state variation during drug development through:

  • Stabilization of unstable polymorphs
  • Optimization of API solid-state properties

In addition, you can rely on our industry-leading Emprove® Program to meet today’s complex regulatory challenges with a superior combination of comprehensive documentation and transparency. Our high-quality raw materials, regulatory expertise, and dedicated support provide everything you need to simplify supplier qualification, speed up processes, and reduce your total cost of ownership.


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