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Levothyroxine dose and measurement of TSH.
Prasanna Santhanam
The American journal of medicine, 128(1), e13-e13 (2015-01-03)
Carla B Schubiger et al.
Applied and environmental microbiology, 81(2), 658-665 (2014-11-09)
Flavobacterium psychrophilum causes bacterial cold-water disease in multiple fish species, including salmonids. An autochthonous Enterobacter strain (C6-6) inhibits the in vitro growth of F. psychrophilum, and when ingested as a putative probiotic, it provides protection against injection challenge with F.
Minna U Kaikkonen et al.
Nucleic acids research, 42(20), 12570-12584 (2014-10-30)
Vascular endothelial growth factor A (VEGF-A) is a master regulator of angiogenesis, vascular development and function. In this study we investigated the transcriptional regulation of VEGF-A-responsive genes in primary human aortic endothelial cells (HAECs) and human umbilical vein endothelial cells
M Taillefer et al.
Applied and environmental microbiology, 81(7), 2423-2432 (2015-01-27)
Clostridium thermocellum produces ethanol as one of its major end products from direct fermentation of cellulosic biomass. Therefore, it is viewed as an attractive model for the production of biofuels via consolidated bioprocessing. However, a better understanding of the metabolic
Kara Lea Vine et al.
Pharmaceutical research, 32(3), 1045-1054 (2014-09-19)
Overexpression of the serine protease urokinase (uPA) is recognised as an important biomarker of metastatic disease and a druggable anticancer target. Plasminogen activator inhibitor type-2 (PAI-2/SerpinB2) is a specific uPA inhibitor with proven potential for use in targeted therapy. However
Ralph S Grand et al.
Nucleic acids research, 42(20), 12585-12599 (2014-10-25)
Successful progression through the cell cycle requires spatial and temporal regulation of gene transcript levels and the number, positions and condensation levels of chromosomes. Here we present a high resolution survey of genome interactions in Schizosaccharomyces pombe using synchronized cells
Martina Koeberl et al.
Journal of immunological methods, 415, 6-16 (2014-12-03)
Food allergies are increasing worldwide, demonstrating a considerable public health concern. Shellfish allergy is one of the major food groups causing allergic sensitization among adults and children, affecting up to 2% of the general world population. Tropomyosin (TM) is the
Sonja Heyerdahl et al.
Thyroid : official journal of the American Thyroid Association, 13(11), 1029-1038 (2003-12-04)
Neonatal screening programs for congenital hypothyroidism (CH) were initiated in the 1970s to ensure early treatment in order to prevent mental retardation. With screening, developmental prognosis is considerably improved, but follow-up studies still report developmental delay compared to controls. To
Melissa M L Wong et al.
PloS one, 10(3), e0122025-e0122025 (2015-03-31)
Lentil (Lens culinaris ssp. culinaris) is a nutritious and affordable pulse with an ancient crop domestication history. The genus Lens consists of seven taxa, however, there are many discrepancies in the taxon and gene pool classification of lentil and its
Xuan Zhuang et al.
Scientific reports, 5, 7922-7922 (2015-01-30)
The aim of this study was to identify mRNA targets of dysregulated miRNAs through the integrated analysis of miRNA and mRNA expression profiling in men with normal versus impaired spermatogenesis. The expression of mRNAs and miRNAs in testicular tissues obtained
Jérôme Gouge et al.
The EMBO journal, 34(8), 1126-1142 (2015-03-13)
Eukaryotic DNA polymerase mu of the PolX family can promote the association of the two 3'-protruding ends of a DNA double-strand break (DSB) being repaired (DNA synapsis) even in the absence of the core non-homologous end-joining (NHEJ) machinery. Here, we
Pharmacotherapy: Levothyroxine in the elderly-finding the breaking point.
Linda Koch
Nature reviews. Endocrinology, 7(8), 435-435 (2011-06-15)
Pradeepraj Durairaj et al.
Enzyme and microbial technology, 70, 58-65 (2015-02-11)
FoCYP53A19, a novel cytochrome P450 capable of performing benzoate hydroxylation, was identified and characterized from the ascomycete Fusarium oxysporum f.sp. lycopersici. Comparative functional analysis of FoCYP53A19 with the heterologous and homologous cytochrome P450 reductases (CPR) such as Saccharomyces cerevisiae (ScCPR)
Jin Duan et al.
FEMS microbiology letters, 361(2), 181-189 (2014-10-21)
Bacteria often have multiple copies of ribosomal RNA (rrn) genes in their genomes. The presence of multiple rrn operons suggests an advantage to the organism, perhaps through adjustable control of protein expression in response to altered environmental conditions. In the
Xiao-Long Zhou et al.
Nucleic acids research, 42(22), 13873-13886 (2014-11-22)
Yeast mitochondria contain a minimalist threonyl-tRNA synthetase (ThrRS) composed only of the catalytic core and tRNA binding domain but lacking the entire editing domain. Besides the usual tRNA(Thr)2, some budding yeasts, such as Saccharomyces cerevisiae, also contain a non-canonical tRNA(Thr)1
Yacong Zhao et al.
International immunopharmacology, 24(2), 219-223 (2014-12-24)
BLyS antagonists have become the therapeutic reagents in the treatment of autoimmune disorders. BLyS binding peptides and their Fc fusion proteins may be alternative BLyS antagonists in such application. In this study, the activity of BLyS binding peptide 814 obtained
Longfei Yang et al.
Drug design, development and therapy, 9, 1319-1330 (2015-03-15)
Breast cancer is considered to be the most common malignancy in women. Treatment of breast cancer has been focused on molecular targeted therapy, and anticancer peptides are considered to be some of the most promising candidate drugs. In the current
Marek Ruchała et al.
Endokrynologia Polska, 63(4), 318-323 (2012-08-31)
The preferred treatment for hypothyroidism is oral levothyroxine (LT4) ingestion, in doses that ensure a sustained state of hormonal balance. Many different factors may significantly influence the absorption of LT4, including: interval between the ingestion of the drug and the
Misook Ha et al.
Epigenetics & chromatin, 7(1), 38-38 (2015-01-20)
The histone variant H3.3 plays a critical role in maintaining the pluripotency of embryonic stem cells (ESCs) by regulating gene expression programs important for lineage specification. H3.3 is deposited by various chaperones at regulatory sites, gene bodies, and certain heterochromatic
Bin Li et al.
BMC genomics, 15, 1086-1086 (2014-12-17)
Quantitative trait locus (QTL) mapping is an efficient approach to discover the genetic architecture underlying complex quantitative traits. However, the low density of molecular markers in genetic maps has limited the efficiency and accuracy of QTL mapping. In this study
Images in clinical medicine. Myxedema.
Joyce Kim
The New England journal of medicine, 372(8), 764-764 (2015-02-19)
Duraisamy Ponnusamy et al.
Infection and immunity, 83(5), 2065-2081 (2015-03-11)
The identification of new virulence factors in Yersinia pestis and understanding their molecular mechanisms during an infection process are necessary in designing a better vaccine or to formulate an appropriate therapeutic intervention. By using a high-throughput, signature-tagged mutagenic approach, we
Sanford Bolton
The AAPS journal, 7(1), E47-E53 (2005-09-09)
The Food and Drug Administration (FDA) Guidance for Bioavailability and Bioequivalence Studies for Levothyroxine has been challenged by companies that manufacture brand-name products. Their contention is that the current guidance does not adequately address the endogenous background levels of the
Yan-Liang Lin et al.
PloS one, 10(4), e0123245-e0123245 (2015-04-11)
Antrodia cinnamomea, a precious, host-specific brown-rot fungus that has been used as a folk medicine in Taiwan for centuries is known to have diverse bioactive compounds with potent pharmaceutical activity. In this study, different fermentation states of A. cinnamomea (wild-type
Laith Q Al-Mawsawi et al.
Retrovirology, 11, 124-124 (2014-12-20)
The HIV-1 pandemic is not the result of a static pathogen but a large genetically diverse and dynamic viral population. The virus is characterized by a highly mutable genome rendering efforts to design a universal vaccine a significant challenge and
Rachel A Okrent et al.
Microbiology (Reading, England), 160(Pt 11), 2432-2442 (2014-08-29)
Pseudomonas fluorescens WH6 secretes a germination-arrest factor (GAF) that we have identified previously as 4-formylaminooxyvinylglycine. GAF irreversibly inhibits germination of the seeds of numerous grassy weeds and selectively inhibits growth of the bacterial plant pathogen Erwinia amylovora. WH6-3, a mutant
Inga Mertens-Walker et al.
Experimental cell research, 333(1), 105-115 (2015-03-01)
The EphB4 receptor tyrosine kinase is over-expressed in a variety of different epithelial cancers including prostate where it has been shown to be involved in survival, migration and angiogenesis. We report here that EphB4 also resides in the nucleus of
Héctor F Escobar-Morreale et al.
The Journal of clinical endocrinology and metabolism, 90(8), 4946-4954 (2005-06-02)
Combined infusion of levothyroxine plus liothyronine, as opposed to levothyroxine alone, is the only way of restoring the concentrations of circulating TSH, T4, and T3 as well as those of both T4 and T3 in all tissues of thyroidectomized rats.
Chris C-S Hsiung et al.
Genome research, 25(2), 213-225 (2014-11-06)
Mitosis entails global alterations to chromosome structure and nuclear architecture, concomitant with transient silencing of transcription. How cells transmit transcriptional states through mitosis remains incompletely understood. While many nuclear factors dissociate from mitotic chromosomes, the observation that certain nuclear factors
Aram Heo et al.
PloS one, 9(10), e110215-e110215 (2014-10-21)
The effects of antibiotics on environment-originated nonpathogenic Acinetobacter species have been poorly explored. To understand the antibiotic-resistance mechanisms that function in nonpathogenic Acinetobacter species, we used an RNA-sequencing (RNA-seq) technique to perform global gene-expression profiling of soil-borne Acinetobacter oleivorans DR1
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