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John Joseph et al.
Nano letters, 15(8), 5420-5426 (2015-07-28)
The present study describes a unique way of integrating substrateless electrospinning process with textile technology. We developed a new collector design that provided a pressure-driven, localized cotton-wool structure in free space from which continuous high strength yarns were drawn. An
Andrew Murley et al.
The Journal of cell biology, 209(4), 539-548 (2015-05-20)
Organelle contact sites perform fundamental functions in cells, including lipid and ion homeostasis, membrane dynamics, and signaling. Using a forward proteomics approach in yeast, we identified new ER-mitochondria and ER-vacuole contacts specified by an uncharacterized protein, Ylr072w. Ylr072w is a
Mir Ali Farajzadeh et al.
Journal of chromatography. A, 1379, 24-33 (2015-01-04)
In this study, for the first time, a dispersive liquid-liquid microextraction technique using a ternary solvent mixture is reported. In order to extract five phthalate esters and di(2-ethylhexyl) adipate with different polarities from aqueous samples, a simplex centroid experimental design
Rokhsana Yasmin et al.
Journal of pharmaceutical sciences, 103(9), 2950-2959 (2014-03-04)
Lyophilization was investigated to produce a powdery silica-lipid hybrid (SLH) carrier for oral delivery of poorly water-soluble drugs. The silica to lipid ratio, incorporation of cryoprotectant, and lipid loading level were investigated as performance indicators for lyophilized SLH carriers. Celecoxib
Christian Johannessen et al.
The journal of physical chemistry. B, 117(7), 2221-2230 (2013-01-25)
The Raman optical activity (ROA) spectra of both enantiomers of 2-Br-hexahelicene in chloroform solution have been measured in the range 1700-300 cm(-1). Density functional theory (DFT) calculations accurately reproduce the observed features. The most intense ROA features are also the
Ilaria Massarelli et al.
European journal of medicinal chemistry, 44(9), 3658-3664 (2009-03-11)
A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above unwanted property for New Chemical Entities. The dataset was rationally split into
Marie de Tayrac et al.
Journal of hepatology, 62(3), 664-672 (2014-12-03)
Hereditary hemochromatosis (HH) is the most common form of genetic iron loading disease. It is mainly related to the homozygous C282Y/C282Y mutation in the HFE gene that is, however, a necessary but not a sufficient condition to develop clinical and
Ni-Chun Chung et al.
PloS one, 10(3), e0118832-e0118832 (2015-03-15)
Homozygous Cav3.2 knockout mice, which are defective in the pore-forming subunit of a low voltage activated T-type calcium channel, have been documented to show impaired maintenance of late-phase long-term potentiation (L-LTP) and defective retrieval of context-associated fear memory. To investigate
Cai-Hua Jia et al.
Journal of agricultural and food chemistry, 63(47), 10280-10286 (2015-10-23)
Caffeic acid phenethyl ester (CAPE) and 4-vinylcatechol (4-VC) were prepared for studying their antioxidative activities in emulsion. Oil-in-water emulsions of stripped soybean oil containing 200 ppm of CAPE, 4-VC, or α-tocopherol were stored at 40 °C in the dark for
Leslie Y Beh et al.
Genome research, 25(11), 1727-1738 (2015-09-04)
A conserved hallmark of eukaryotic chromatin architecture is the distinctive array of well-positioned nucleosomes downstream from transcription start sites (TSS). Recent studies indicate that trans-acting factors establish this stereotypical array. Here, we present the first genome-wide in vitro and in
Marjolein A Wijngaarden et al.
American journal of physiology. Endocrinology and metabolism, 307(10), E885-E895 (2014-09-25)
During fasting, rapid metabolic adaptations are required to maintain energy homeostasis. This occurs by a coordinated regulation of energy/nutrient-sensing pathways leading to transcriptional activation and repression of specific sets of genes. The aim of the study was to investigate how
Andrew V Caprariello et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(41), 14031-14041 (2015-10-16)
During mammalian development, myelin-forming oligodendrocytes are generated and axons ensheathed according to a tightly regulated sequence of events. Excess premyelinating oligodendrocytes are eliminated by apoptosis and the timing of the onset of myelination in any specific CNS region is highly
Gerhard Liebisch et al.
Journal of lipid research, 56(6), 1234-1239 (2015-04-03)
In general, mass spectrometric quantification of small molecules in routine laboratory testing utilizes liquid chromatography coupled to low mass resolution triple-quadrupole mass spectrometers (QQQs). Here we introduce high-resolution tandem mass spectrometry (quadrupole-Orbitrap) for the quantification of 25-hydroxy-vitamin D [25(OH)D], a
Pablo R S Oliveira et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2664-2672 (2015-02-13)
The outcome of Leishmania infections varies substantially, depending on the host and the parasite strain; infection may be asymptomatic or cause mild or severe skin ulcers (cutaneous leishmaniasis [CL]), limited or disseminated lesions, or lethal visceral disease. We previously reported
Yanzhuo Zhang et al.
Pharmaceutical research, 32(7), 2372-2383 (2015-01-23)
A novel mesoporous carbon/lipid bilayer nanocomposite (MCLN) with a core-shell structure was synthesized and characterized as an oral drug delivery system for poorly water-soluble drugs. The objective of this study was to investigate the potential of MCLN-based formulation to modulate
Thomas W Phillips et al.
Lab on a chip, 15(14), 2960-2967 (2015-06-10)
We report the use of a porous polytetrafluoroethylene capillary for the inline separation of liquid-liquid segmented flows, based on the selective wetting and permeation of the porous capillary walls by one of the liquids. Insertion of a narrow flow restriction
Mary A Forget et al.
PloS one, 9(6), e98623-e98623 (2014-06-04)
Reports demonstrate the role of M-CSF (CSF1) in tumor progression in mouse models as well as the prognostic value of macrophage numbers in breast cancer patients. Recently, a subset of CD14+ monocytes expressing the Tie2 receptor, once thought to be
Jaime H Gibbs et al.
Journal of organometallic chemistry, 798(Pt 1), 209-213 (2015-12-22)
A series of four BODIPYs containing one or two
Jonah Piovia-Scott et al.
The ISME journal, 9(7), 1570-1578 (2014-12-17)
The fungal pathogen Batrachochytrium dendrobatidis (Bd) has caused declines and extinctions in amphibians worldwide, and there is increasing evidence that some strains of this pathogen are more virulent than others. While a number of putative virulence factors have been identified
Line Hagner Nielsen et al.
Drug delivery and translational research, 4(3), 268-274 (2015-03-20)
Amorphous indomethacin was prepared by melting the γ-form of indomethacin, spatially confined within microcontainers (inner diameter of 223 μm), followed by cooling of the melt at a rate of 14, 23 or 36 K/min. The physical stability of the amorphous indomethacin within
Jia Xin Chua et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(13), 2963-2974 (2015-03-18)
To produce antitumor monoclonal antibodies (mAbs) targeting glycans as they are aberrantly expressed in tumors and are coaccessory molecules for key survival pathways. Two mAbs (FG88.2 and FG88.7) recognizing novel tumor-associated Lewis (Le) glycans were produced by immunizations with plasma
Hideyuki Takeshima et al.
Cancer letters, 357(1), 328-338 (2014-12-03)
A field for cancerization, or a field defect, is formed by the accumulation of genetic and epigenetic alterations in normal-appearing tissues, and is involved in various cancers, especially multiple cancers. Epigenetic alterations are frequently present in chronic inflammation-exposed tissues, but
Andrew L Kau et al.
Science translational medicine, 7(276), 276ra24-276ra24 (2015-02-27)
To gain insights into the interrelationships among childhood undernutrition, the gut microbiota, and gut mucosal immune/barrier function, we purified bacterial strains targeted by immunoglobulin A (IgA) from the fecal microbiota of two cohorts of Malawian infants and children. IgA responses
X Han et al.
Cancer gene therapy, 22(3), 122-129 (2015-01-24)
MicroRNAs (miRNAs) are important regulators that play key roles in tumorigenesis and tumor progression. In this study, we investigate whether let-7b acts as a tumor suppressor to inhibit invasion and metastasis in gastric cancers. We analyzed the expression of let-7b
Lorena Claumarchirant et al.
Journal of agricultural and food chemistry, 63(32), 7245-7251 (2015-08-06)
Sterol contents in infant formulas (IFs) from the European market were determined, and their intakes by infants between 0 and 6 months were evaluated. Total animal sterols (mg/100 mL) ranged from 1.71 to 5.46, cholesterol being the main animal sterol
Neva B Watson et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2796-2809 (2015-02-15)
Virus-induced myositis is an emerging global affliction that remains poorly characterized with few treatment options. Moreover, muscle-tropic viruses often spread to the CNS, causing dramatically increased morbidity. Therefore, there is an urgent need to explore genetic factors involved in this
Yohei Abe et al.
Nature communications, 6, 7052-7052 (2015-05-08)
Histone 3 lysine 9 (H3K9) demethylase JMJD1A regulates β-adrenergic-induced systemic metabolism and body weight control. Here we show that JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate the β1-adrenergic receptor gene (Adrb1)
Udi Jumhawan et al.
Journal of bioscience and bioengineering, 120(5), 555-561 (2015-04-29)
Development of authenticity screening for Asian palm civet coffee, the world-renowned priciest coffee, was previously reported using metabolite profiling through gas chromatography/mass spectrometry (GC/MS). However, a major drawback of this approach is the high cost of the instrument and maintenance.
A T Nasr et al.
Physics in medicine and biology, 60(12), 4665-4683 (2015-05-29)
Radiochromic leuco crystal violet (LCV) micelle gel dosimeters are promising three-dimensional radiation dosimeters because of their spatial stability and suitability for optical readout. The effects of surfactant type and surfactant concentration on dose sensitivity of LCV micelle gels are tested
Jennifer Mahony et al.
Applied and environmental microbiology, 81(10), 3299-3305 (2015-03-10)
Lactococcal bacteriophages represent one of the leading causes of dairy fermentation failure and product inconsistencies. A new member of the lactococcal 949 phage group, named WRP3, was isolated from cheese whey from a Sicilian factory in 2011. The genome sequence
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