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Woo-Ram Lee et al.
Biochemical and biophysical research communications, 450(1), 195-201 (2014-06-01)
Apamin is an integral part of bee venom, as a peptide component. It has long been known as a highly selective block Ca(2+)-activated K(+) (SK) channels. However, the cellular mechanism and anti-fibrotic effect of apamin in TGF-β1-induced hepatocytes have not
Yanmang Cui et al.
Chemico-biological interactions, 220, 75-83 (2014-06-29)
The study was to characterize the polyphenolic composition, antioxidant properties, and hepatoprotective effects of a polyphenols-enriched extract (HMTP) from Huangshan Maofeng green tea. HPLC analysis showed that three predominantly polyphenolic compounds present in HMTP were epigallocatechin (271.2 μg/mg extract), rutin
Fujun Yu et al.
The Journal of biological chemistry, 290(47), 28286-28298 (2015-10-09)
Effective control of hepatic stellate cell (HSC) activation and proliferation is critical to the treatment of liver fibrosis. Long non-coding RNAs have been shown to play a pivotal role in the regulation of cellular processes. It has been reported that
Alastair J O'Brien et al.
Nature medicine, 20(5), 518-523 (2014-04-15)
Liver disease is one of the leading causes of death worldwide. Patients with cirrhosis display an increased predisposition to and mortality from infection due to multimodal defects in the innate immune system; however, the causative mechanism has remained elusive. We
Sebastian Huss et al.
BMC gastroenterology, 13, 8-8 (2013-01-15)
Four and one half LIM domain protein 2 (FHL2) has been reported to be a key regulator in many cellular processes being associated with fibrogenesis such as cell migration and contraction. Moreover, hepatic FHL2 is involved in regulation pathways mediating
Taichiro Nishikawa et al.
Journal of hepatology, 60(6), 1203-1211 (2014-03-04)
The cause of hepatic failure in the terminal stages of chronic injury is unknown. Cellular metabolic adaptations in response to the microenvironment have been implicated in cellular breakdown. To address the role of energy metabolism in this process we studied
Hua Liu et al.
World journal of gastroenterology, 20(48), 18189-18198 (2015-01-07)
To investigate the role of caspase-12 and its downstream targets in carbon tetrachloride (CCl4)-induced hepatocyte apoptosis. The role of caspase-12 was determined by using caspase-12 knock-out ((-/-)) mice. CCl4 (300 μL/kg body weight) or vehicle (corn oil) was administered to
Rui Jia et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 11-19 (2014-04-12)
In the present study, the cellular and molecular mechanism of carbon tetrachloride (CCl4)-induced hepatotoxicity in fish was investigated by studying the effects of CCl4 on the oxidative stress, inflammatory response and hepatocyte apoptosis. Common carp were given an intraperitoneal injection
Peng Liu et al.
In vitro cellular & developmental biology. Animal, 50(10), 899-908 (2014-08-26)
To investigate the effects of icaritin, an active ingredient extracted from Epimedium Sagittatum (Sieb. et Zucc.), on CCl4-induced liver injury and its possible mechanisms. Hepatocytes isolated from Sprague-Dawley male rats were treated with 3 mmol/L CCl4 for 24 h to
Mingjiang Wu et al.
International journal of biological macromolecules, 56, 28-33 (2013-02-12)
Water-soluble polysaccharides were isolated from the brown alga Hizikia fusiformis and separated using hydrophobic chromatography on an ME-1 resin column. Three major polysaccharide fractions, FG, GM-1 and GM-2, were analyzed by high-performance liquid chromatography, Fourier-transform infrared and (13)C nuclear magnetic
Chunmei Ma et al.
Life sciences, 108(2), 104-108 (2014-06-03)
To evaluate the hepatocyte phase of Gd-EOB-DTPA-enhanced MRI in the early diagnosis of hepatic fibrosis and cirrhosis and assessment of liver function in a rat model. In 2 groups of SD rats, liver fibrosis was induced in experimental animals by
Eugenio Rosado et al.
Hepatology (Baltimore, Md.), 58(4), 1424-1435 (2013-05-25)
Increased production of vasoconstrictive prostanoids, such as thromboxane A2 (TXA2 ), contributes to endothelial dysfunction and increased hepatic vascular tone in cirrhosis. TXA2 induces vasoconstriction by way of activation of the thromboxane-A2 /prostaglandin-endoperoxide (TP) receptor. This study investigated whether terutroban
Roy S Thompson et al.
Environmental monitoring and assessment, 97(1-3), 23-38 (2004-09-21)
This risk assessment on carbon tetrachloride was carried out specifically for the marine environment, according to the methodology laid down in the European Union (EU) risk assessment Regulation (1488/94) and the Technical Guidance Documents for New and Existing Substances (TGD
Rajesh Krithika et al.
Toxicology mechanisms and methods, 25(9), 708-717 (2015-09-05)
Chronic injury to liver triggers synthesis of extracellular matrix components resulting in progressive fibrosis and eventually cirrhosis. Transforming growth factor-β1 (TGF-β1) transduces its signal by binding to TGF-β type 1 receptor kinase or activin like kinase (ALK5) receptor and mediates
Souad E El-Gengaihi et al.
Journal of dietary supplements, 10(1), 39-53 (2013-02-20)
This study was designed to investigate the potential of Physalis peruviana root as a functional food with hepato-renal protective effects against fibrosis. The chemical composition of the plant root suggested the presence of alkaloids, withanolides and flavonoids. Five compounds were
Inmaculada Lopez-Sanchez et al.
Nature communications, 5, 4451-4451 (2014-07-22)
Progressive liver fibrosis is characterized by the deposition of collagen by activated hepatic stellate cells (HSCs). Activation of HSCs is a multiple receptor-driven process in which profibrotic signals are enhanced and antifibrotic pathways are suppressed. Here we report the discovery
Josef Ehling et al.
Gut, 63(12), 1960-1971 (2014-02-25)
In chronic liver injury, angiogenesis, the formation of new blood vessels from pre-existing ones, may contribute to progressive hepatic fibrosis and to development of hepatocellular carcinoma. Although hypoxia-induced expression of vascular endothelial growth factor (VEGF) occurs in advanced fibrosis, we
Peter I Nagy
The journal of physical chemistry. A, 117(13), 2812-2826 (2013-03-14)
The present case study aims at calculating the equilibrium conformer compositions for 2X-ethanol and 2X-phenol (X = F, Cl) in solution, and exploring the effect of the applied theoretical method and basis set on the obtained results, as well as
Mir Ali Farajzadeh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 983-984, 55-61 (2015-01-27)
The present work is based on a one-step method including derivatization and solid-based disperser liquid-liquid microextraction followed by gas chromatography-flame ionization detection (GC-FID) for the determination of four antidepressants (fluoxetine, fluvoxamine, tranylcypromine, and nortriptyline) and an antiarrhythmic agent (mexiletine) in
S C Cunnane
Alcoholism, clinical and experimental research, 11(1), 25-31 (1987-02-01)
Triacylglycerol accumulation in the liver (fatty liver) caused by ethanol or carbon tetrachloride involves interactions with essential fatty acids and prostaglandins. The degree to which the fatty liver develops is dependent on total dietary fat intake. Both ethanol and carbon
Inge Mannaerts et al.
PloS one, 8(1), e55786-e55786 (2013-02-06)
The conversion of a quiescent vitamin A storing hepatic stellate cell (HSC) to a matrix producing, contractile myofibroblast-like activated HSC is a key event in the onset of liver disease following injury of any aetiology. Previous studies have shown that
Tomoko Yamazaki et al.
PloS one, 9(10), e109123-e109123 (2014-10-11)
Hepatocellular carcinoma (HCC), the fifth most common cancer type and the third highest cause of cancer death worldwide, develops in different types of liver injuries, and is mostly associated with cirrhosis. However, non-alcoholic fatty liver disease often causes HCC with
Baode Shen et al.
The Journal of pharmacy and pharmacology, 65(9), 1382-1392 (2013-08-10)
The main purpose of this study was to enhance the intestinal absorption activity and hepatoprotective effect of herpetrione by drug nanosuspensions. Herpetrione nanosuspensions (HNS) were prepared using pH-dependent dissolving-precipitating/homogenization process and then systematically characterized. The intestinal absorption activity of HNS
Meritxell Huch et al.
Nature, 494(7436), 247-250 (2013-01-29)
The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon, stomach and hair follicles. A three-dimensional culture system allows long-term clonal expansion of single Lgr5(+) stem
Dane R Letourneau et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 14(11), 2108-2118 (2015-10-07)
The photochemically mediated dechlorination of polyhalogenated compounds represents a potential decontamination strategy and a relevant environmental process in chemically reducing media. We report the UV irradiation of natural and artificial waters containing natural dissolved organic matter to effect the photo-sensitized
Mark A Barnes et al.
Journal of leukocyte biology, 97(1), 161-169 (2014-11-16)
Recruitment of peripheral monocytes to the liver is a key contributor to the response to injury. MIF can act as a chemokine and cytokine, regulating innate immune responses in many tissues and cell types. We hypothesized that MIF contributes to
Xinhui Wang et al.
Environmental toxicology and pharmacology, 36(2), 288-295 (2013-05-21)
This study aimed to investigate the effects of galangin on liver fibrosis in rats induced by subcutaneous injection of carbon tetrachloride (CCl4). The administration of CCl4 to rats for 12 weeks caused significant increase of hyaluronic acid, laminin, alanine transaminase
Ahmed E Abdel Moneim et al.
Journal of physiology and biochemistry, 69(3), 359-370 (2012-11-08)
The purpose of this study was to evaluate the effect of pomegranate (Punica granatum) in inhibiting and reversing the nephrotoxicity of carbon tetrachloride, a potent oxidative stress inducer which induces cellular kidney damage. Rats were intraperitoneally injected with carbon tetrachloride
W J Brattin et al.
Journal of free radicals in biology & medicine, 1(1), 27-38 (1985-01-01)
Liver cell injury induced by carbon tetrachloride involves initially the metabolism of carbon tetrachloride to trichloromethyl free-radical by the mixed function oxidase system of the endoplasmic reticulum. It is postulated that secondary mechanisms link carbon tetrachloride metabolism to the widespread
Arya J Bahrami et al.
PloS one, 9(10), e108505-e108505 (2014-10-08)
Liver fibrosis is mediated by hepatic stellate cells (HSCs), which respond to a variety of cytokine and growth factors to moderate the response to injury and create extracellular matrix at the site of injury. G-protein coupled receptor (GPCR)-mediated signaling, via
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