Search Within
Applied Filters:
Showing 1-30 of 41 results for "


" within Papers
Induction of an endogenous B-tropic type C RNA virus from SWR/J mouse embryo cells in tissue culture.
J R Stephenson et al.
Virology, 70(2), 352-359 (1976-04-01)
Synthesis, characterization, and in-vitro antitumor activity of the polyethylene glycol (350 and 1000) succinate derivatives of the tocopherol and tocotrienol isomers of Vitamin E
Abu-Fayyad A and Nazzal S
International Journal of Pharmaceutics, 519(1-2), 145-156 (2017)
Liyan Zhao et al.
Journal of biomedical nanotechnology, 7(3), 358-365 (2011-08-13)
The objective of this study was to develop a polymeric delivery system to improve the solubility and biological activity of Quercetin (QT). QT loaded mixed micelles, composed of Pluronic P123 (P123) and D-a-tocopheryl polyethylene glycol succinate (TPGS) with proportion of
Anandhkumar Raju et al.
Expert opinion on drug delivery, 10(6), 747-760 (2013-03-06)
In this study, the authors developed D-α-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS or simply TPGS) liposomes and further conjugated them to trastuzumab for controlled and targeted delivery of docetaxel (DTX) as a model hydrophobic drug. DTX- or coumarin-6-loaded
Carmine Ostacolo et al.
International journal of pharmaceutics, 440(2), 148-153 (2012-10-11)
Corneal accumulation of riboflavin-5'-phosphate (riboflavin) is an essential step in the so called corneal cross-linking (CXL), an elective therapy for the treatment of progressive keratoconus, corneal ectasia and irregular astigmatism. CXL is usually performed after surgical debridement of corneal epithelium
Preetanshu Pandey et al.
Pharmaceutical development and technology, 18(1), 296-304 (2012-11-10)
The objective of this study is to investigate processing challenges associated with the incorporation of Vitamin E TPGS (d-α tocopheryl polyethylene glycol 1000 succinate) into solid pharmaceutical dosage forms. For this work, a wet granulation process (high-shear and fluid bed)
Massimiliano di Cagno et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 775-780 (2013-01-29)
The objective of this study was to investigate if the increase in apparent solubility induced by liposomalization or micellization of the poorly soluble drug hydrocortisone (HC) would lead to an enhancement of its permeability through biological membranes. For this purpose
Shota Kodani et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(30), 7164-7176 (2017-06-24)
Emotionally salient situations usually trigger arousal along with autonomic and neuroendocrine reactions. To determine whether the extended amygdala plays a role in sleep-wakefulness regulation, we examined the effects of optogenetic and pharmacogenetic excitation of GABAergic neurons in the bed nucleus
Xin Jin et al.
Drug development and industrial pharmacy, 39(9), 1421-1430 (2012-10-13)
Baohuoside I is an effective anti-cancer drug currently used for a variety of cancers in vitro. Unfortunately, baohuoside I has a very poor solubility in both water and in organic solvents. Besides that, it is subject to significant efflux. This
Were L L Munyendo et al.
Journal of biomedical nanotechnology, 9(12), 2034-2047 (2013-11-26)
Mixed micelles were designed to increase oral bioavailability of Apigenin (Ap). The phospholipid (Ph) complex technology was exploited alongside TPGS' stabilizing effect by PEG chain sterical hindrance of the phase II enzymes. This prevented extensive metabolism of Ap while inhibiting
Slobodan Šašić et al.
Journal of pharmaceutical and biomedical analysis, 70, 273-279 (2012-08-09)
Infrared spectroscopy is used to monitor the dissolution of the Active Pharmaceutical Ingredient (API) and an excipient (vitamin E - TPGS) during manufacturing of a liquid pharmaceutical formulation. The goal of the analysis is to explore options for real-time, on
Chenming Yang et al.
Journal of biomedical nanotechnology, 9(9), 1617-1623 (2013-08-29)
The purpose of this research was to investigate the possibility of dexamethasone (DEX)-loaded PLGA-TPGS nanoparticles (NPs) in rabbits after intravitreal administration for the treatment of posterior segment diseases. The DEX-loaded PLGA-TPGS NPs were fabricated and characterized in terms of surface
Maya George et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 142-152 (2012-10-23)
Wet media milling by top down method has proved to be an effective method to prepare nanosuspension of poorly soluble drugs/APIs. Few or no attempts have been made so far to understand the feasibility of nanosuspension formulation in terms of
Coy P McNew et al.
Journal of colloid and interface science, 526, 207-219 (2018-05-08)
Poly(lactic-co-glycolic acid) (PLGA) particle carriers of synthetic DNA have recently received increased attention for environmental applications due to their biodegradability, customizability, and nearly limitless number of uniquely identifiable "labels". In this paper, we present methodologies for the preparation of DNA-labeled
Heni Rachmawati et al.
Journal of pharmaceutical sciences, 102(1), 204-214 (2012-10-11)
Curcumin, a naturally occuring polyphenolic phytoconstituent, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). It is water insoluble under acidic or neutral conditions but dissolves in alkaline environment. In neutral or alkaline conditions, curcumin is highly unstable undergoing
Jianan Shen et al.
Biomaterials, 33(33), 8613-8624 (2012-08-23)
Drug resistance is a main obstacle for the successful chemotherapy of lung cancer. In this work, a new co-delivery system, P85-PEI/TPGS/PTX/shSur complex nanoparticles (PTPNs), to overcome paclitaxel (PTX) resistance in A549 human lung cancer was designed and developed. The experimental
Fady Ibrahim et al.
Drug development and industrial pharmacy, 39(9), 1277-1283 (2012-09-20)
The objective of this study was to assess the pharmacokinetics and tissue distribution of amphotericin B (AmB) in rats following oral administration of three lipid-based formulations (iCo-009, iCo-010 and iCo-011). The lipid-based formulations were administered to rats at a dose
Vipin Saxena et al.
Journal of biomedical nanotechnology, 9(7), 1146-1154 (2013-08-06)
The biggest challenge for the treatment of multidrug resistance cancer is to deliver high concentration of anticancer drugs specifically to cancer cells for longer period of time. Poloxamers and D-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS) are known inhibitors of P-glycoprotein.
Chandrasekharan Prashant et al.
Biomaterials, 31(21), 5588-5597 (2010-05-04)
We developed a strategy to formulate supraparamagnetic iron oxides (SPIOs) in nanoparticles (NPs) of biodegradable copolymer made up of poly(lactic acid) (PLA) and d-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) for medical imaging by magnetic resonance imaging (MRI) of high contrast
Yu Mi et al.
International journal of pharmaceutics, 438(1-2), 98-106 (2012-09-08)
Double emulsion has been used most often in formulation of hydrophilic drugs by nanoparticles of biodegradable polymers, which has disadvantages such as low drug loading and low drug encapsulation efficiency due to the drug loss in the process. The drug
Jianan Shen et al.
Biomaterials, 34(5), 1581-1590 (2012-11-14)
The metastasis of breast cancer is the leading cause of cancer death in women, and the lung is a common location of a secondary tumor that has metastasized from the primary source tumor. In this work, an attempt to simultaneously
Paolo Fogagnolo et al.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 229(1), 26-31 (2012-09-27)
To evaluate the postoperative effects of topical coenzyme Q(10) + vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate (CoQ(10)) after cataract surgery. 40 consecutive patients were randomized to receive CoQ(10) or saline solution (SS) twice daily for 9 months after uneventful
Christiana M Neophytou et al.
Biochemical pharmacology, 89(1), 31-42 (2014-02-25)
D-alpha-tocopheryl polyethylene glycol succinate (TPGS) is a vitamin E derivative that has been intensively applied as a vehicle for drug delivery systems to enhance drug solubility and increase the oral bioavailability of anti-cancer drugs. Recently, it has been reported that
Eun-Hye Lee et al.
Archives of pharmacal research, 35(9), 1639-1644 (2012-10-12)
Tocopherol analogs are known to have pleiotropic effects due to its interaction with diverse intracellular targets. Previously we reported that low/subapoptotic dose of α-tocopheryl succinate (αTOS) inhibits cyclooxygenase (COX) and prostaglandin E₂ (PGE₂) production in lung epithelial cells, while high
Aihui Yan et al.
Carbon, 45(13), 2463-2470 (2008-12-17)
This work investigates the physical interactions between carbon nanomaterials and tocopheryl polyethylene glycol succinate (TPGS). TPGS is a synthetic amphiphile that undergoes enzymatic cleavage to deliver the lipophilic antioxidant, alpha-tocopherol (vitamin E) to cell membranes, and is FDA approved as
Tiechuang Wang et al.
International journal of nanomedicine, 7, 2325-2337 (2012-06-05)
Emodin is a multifunctional Chinese traditional medicine with poor water solubility. D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) is a pegylated vitamin E derivate. In this study, a novel liposomal-emodin-conjugating TPGS was formulated and compared with methoxypolyethyleneglycol 2000-derivatized distearoyl-phosphatidylethanolamine (mPEG2000-DSPE) liposomal
Xiaoli Wang et al.
Drug development and industrial pharmacy, 39(9), 1408-1413 (2012-07-24)
The therapeutic efficiency of mangiferin is restricted by its low intestinal permeability. In order to improve the oral absorption of mangiferin, potential of enhancers, including TPGS, sodium deoxycholate and Carbopol 974P, were investigated in a series of in vivo experiments.
Ying Wang et al.
Nanotechnology, 23(49), 495103-495103 (2012-11-15)
Multidrug resistance (MDR) is one of the factors in the failure of anticancer chemotherapy. In order to enhance the anticancer effect of P-glycoprotein (P-gp) substrates, inhibition of the P-gp efflux pump on MDR cells is a good tactic. We designed
Zhuoyang Fan et al.
International journal of pharmaceutics, 445(1-2), 141-147 (2013-02-12)
The purpose of this study was to examine whether Vitamin E-TPGS had a function in promoting the secretion of chylomicrons in enterocytes. Therefore, we simulated the human intestinal epithelial cells by Caco-2 cell model to study the effect of Vitamin
Pengfei Xu et al.
International journal of pharmaceutics, 454(1), 21-30 (2013-07-09)
Tumor metastasis is the leading cause of breast cancer-related mortality and remains to be the principal obstacle for the successful chemotherapy of breast cancer. To block metastasis of breast cancer, silibinin-loaded lipid nanoparticles (SLNs) containing TPGS and phosphatidylcholine were designed
Page 1 of 2
Page 1 of 2