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Ariel Finkielsztein et al.
Immunology letters, 163(1), 84-95 (2014-12-03)
Platelets, like stromal cells, present antigen only via MHC class I, but the immune potential of their progenitors has not been explored in humans. We derived CD34(+)CD117(+)CD41(+)CD151(+) megakaryocyte progenitors (MKp) in vitro from mobilized peripheral blood hematopoietic stem and progenitor
Rodrigo Liberal et al.
Hepatology (Baltimore, Md.), 62(3), 863-875 (2015-05-09)
Defective immune regulation plays a permissive role enabling effector cells to initiate and perpetuate tissue damage, eventually resulting in autoimmune disease. Numerical and functional regulatory T-cell (Treg) impairment has been previously reported in autoimmune liver disease (AILD; including autoimmune hepatitis
Heng Chi et al.
Fish & shellfish immunology, 47(1), 321-330 (2015-09-15)
The interleukin (IL)-17 cytokine family participates in the regulation of many cellular functions. In the present study, we analyzed the genomic structure, expression, and promoter activity of four IL-17 members from the teleost fish tongue sole (Cynoglossus semilaevis), i.e. CsIL-17C
Béatrice Gagnaire et al.
Ecotoxicology (London, England), 24(1), 215-231 (2014-10-29)
To characterize environmental risks linked to former uranium mines in the Limousin region of France, a study was conducted on fish health effects from uranium releases. Two private ponds were compared in this study, one with uranium contamination and one
Priyanka Gaur et al.
Clinical immunology (Orlando, Fla.), 161(2), 163-169 (2015-08-06)
Enthesitis related arthritis (ERA) is associated with increased frequency of Th17 cells and synovial fluid (SF) IL-17 levels. Natural killer (NK) and gamma delta T cells have been recently shown to produce IL-17, thus we studied the NK and gamma
Kai Yang et al.
Journal of virology, 89(18), 9393-9406 (2015-07-03)
Both HIV-1 virions and infected cells use their surface regulators of complement activation (RCA) to resist antibody-dependent complement-mediated lysis (ADCML). Blockage of the biological function of RCA members, particularly CD59 (a key RCA member that controls formation of the membrane
Mengyuan Liu et al.
Cancer immunology research, 9(5), 542-553 (2021-03-03)
Type I IFNs are implicated in tumor immunogenicity and response to systemic therapy, but their interaction with oncogene signaling is not well understood. Here, we studied oncogenic KIT, which drives gastrointestinal stromal tumor (GIST), the most common sarcoma. Using mouse
Tue Kruse Rasmussen et al.
Arthritis research & therapy, 17, 154-154 (2015-06-10)
Interleukin (IL)-21 is a key cytokine in autoimmune diseases such as systemic lupus erythematosus (SLE) by its regulation of autoantibody production and inflammatory responses. The objective of this study is to investigate the signaling capacity of IL-21 in T and
David J Huss et al.
Journal of immunology (Baltimore, Md. : 1950), 194(1), 84-92 (2014-11-25)
Regulatory T cells (Tregs) mediate immune tolerance to self and depend on IL-2 for homeostasis. Treg deficiency, dysfunction, and instability are implicated in the pathogenesis of numerous autoimmune diseases. There is considerable interest in therapeutic modulation of the IL-2 pathway
Weiwei Zhang et al.
Parasites & vectors, 8, 37-37 (2015-01-22)
Schistosomiasis is a chronic parasitic disease that affects approximately 200 million people. In Schistosomiasis japonica and mansoni, parasite eggs were trapped in host liver and stimulated the CD4(+)T cell responses to regulate the formation of the granulomas. Subsequently, excessive granulomatous
E Seccareccia et al.
Oncogenesis, 3, e116-e116 (2014-08-19)
The factors that determine the ability of metastatic tumor cells to expand and grow in specific secondary site(s) are not yet fully understood. Matrix metalloproteinases (MMP) were identified as potential regulators of the site-specificity of metastasis. We found that lung
Peitao Zhou et al.
Frontiers in cell and developmental biology, 8, 56-56 (2020-03-03)
Macrophage-orchestrated chronic inflammation plays an important role in cardiovascular disease, including accelerating the development of calcific aortic valve disease (CAVD). M1 and M2 macrophage polarization imbalances can alter intensity of inflammatory responses. Recombinant human interleukin 37 (IL-37) could be involved
Yuji Nozaki et al.
American journal of physiology. Renal physiology, 308(8), F899-F909 (2015-02-05)
Nephrotoxicity is a frequent complication of cisplatin-induced chemotherapy, in which T cells are known to promote acute kidney injury (AKI). Apoptosis and necrosis of tubules and inflammatory events also contribute to the nephrotoxicity. A delineation of the mechanisms that underlie
Yutaka Kimura et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(5), 759-768 (2014-03-08)
We established a luciferase reporter assay system, the Multi-ImmunoTox Assay (MITA), to evaluate the effects on key predictivein vitro components of the human immune system. The system is composed of 3 stable reporter cell lines transfected with 3 luciferase genes
Dàlia Raïch-Regué et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4767-4776 (2015-04-05)
The mammalian/mechanistic target of rapamycin (mTOR) is a key integrative kinase that functions in two independent complexes, mTOR complex (mTORC) 1 and mTORC2. In contrast to the well-defined role of mTORC1 in dendritic cells (DC), little is known about the
M Tahara et al.
Clinical and experimental immunology, 179(2), 197-209 (2014-09-16)
Programmed cell death-1 (PD-1) plays an important role in peripheral T cell tolerance, but whether or not it affects the differentiation of helper T cell subsets remains elusive. Here we describe the importance of PD-1 in the control of T
Yuan Xiao Zhu et al.
Blood, 125(3), 483-491 (2014-11-15)
To identify molecular targets that modify sensitivity to lenalidomide, we measured proliferation in multiple myeloma (MM) cells transfected with 27 968 small interfering RNAs in the presence of increasing concentrations of drug and identified 63 genes that enhance activity of lenalidomide
Louis Pérol et al.
Immunology letters, 162(2 Pt B), 173-184 (2014-12-03)
Low-dose IL-2 administration can control autoimmunity by specifically activating CD4(+) Foxp3(+) regulatory T cells (Tregs). Here, we studied IL-2-based immunotherapy in experimental graft-versus-host disease (GVHD). IL-2 administration to donor mice induced a dose-dependent expansion of Tregs in the graft but
Therese S Salameh et al.
Journal of Alzheimer's disease : JAD, 47(3), 715-728 (2015-09-25)
Intranasal insulin has shown efficacy in patients with Alzheimer's disease (AD), but there are no preclinical studies determining whether or how it reaches the brain. Here, we showed that insulin applied at the level of the cribriform plate via the
Sarah Fox et al.
Journal of inflammation (London, England), 12, 51-51 (2015-09-12)
Gastric epithelial cells (GECs) undergo apoptosis during H. pylori infection and phagocytes within the mucosa engulf these cells. The recognition and clearance of apoptotic cells is a multifactorial process, enhanced by the presence of various bridging molecules and opsonins which
Irene Lisovsky et al.
Journal of virology, 89(19), 9909-9919 (2015-07-24)
Epidemiological and functional studies implicate NK cells in HIV control. However, there is little information available on which NK cell populations, as defined by the inhibitory NK cell receptors (iNKRs) they express, respond to autologous HIV-infected CD4(+) (iCD4) T cells.
S Gutierrez-Hincapié et al.
Allergologia et immunopathologia, 43(6), 553-561 (2015-03-23)
Autosomal dominant hyper-IgE syndrome (AD-HIES) is a primary immunodeficiency mainly caused by mutations in STAT3, a signalling molecule implicated in the development of appropriate immune responses. We aimed to characterise the innate immune response in AD-HIES. The frequency of innate
Minos-Timotheos Matsoukas et al.
Science signaling, 8(382), ra63-ra63 (2015-06-25)
Calcineurin (CN), a serine and threonine protein phosphatase that depends on Ca(2+) and calmodulin for its activity, is the target of the immunosuppressant drugs cyclosporin A (CsA) and tacrolimus (FK506). CN dephosphorylates and activates members of the NFATc (nuclear factor
Yonglian Sun et al.
Science signaling, 8(405), ra122-ra122 (2015-12-03)
Interleukin-2 (IL-2)-inducible T cell kinase (ITK) mediates T cell receptor (TCR) signaling primarily to stimulate the production of cytokines, such as IL-4, IL-5, and IL-13, from T helper 2 (TH2) cells. Compared to wild-type mice, ITK knockout mice are resistant
Marta Martínez-Abadía et al.
Physical chemistry chemical physics : PCCP, 17(17), 11715-11724 (2015-04-15)
Fluorescent bent-core molecules, bearing one or two cyanostilbene units in the lateral structure and different positions of the cyano group (α- or β-isomers), are described with the aim of modulating the molecular packing and fluorescence properties. These compounds give rise
Marion Weber-Boyvat et al.
Experimental cell research, 331(2), 278-291 (2014-12-03)
ORP3 is an R-Ras interacting oxysterol-binding protein homolog that regulates cell adhesion and is overexpressed in several cancers. We investigated here a novel function of ORP3 dependent on its targeting to both the endoplasmic reticulum (ER) and the plasma membrane
Y S Lee et al.
Toxicology and applied pharmacology, 284(2), 254-261 (2015-01-13)
Sodium meta-arsenite (SA) is an orally available arsenic compound. We investigated the effects of SA on the development of autoimmune type 1 diabetes. Female non-obese diabetic (NOD) mice were orally intubated with SA (5mg/kg/day) from 8weeks of age for 8weeks.
Huining Wang et al.
Molecular medicine reports, 20(5), 4271-4276 (2019-09-24)
The present study aimed to explore the mechanisms through which microRNA (miR)‑20a may be involved in the differentiation of THP‑1 human acute monocytic leukemia cells into osteoclasts. THP‑1 cells were differentiated into macrophages (osteoclast precursors) and subsequently into osteoclast cells.
Hee-Yun Kim et al.
American journal of rhinology & allergy, 29(3), e87-e94 (2015-05-16)
Allergic rhinitis (AR) is an allergic inflammatory disease induced by various mediators released by infiltrating inflammatory cells. Vascular endothelial growth factor (VEGF) increases the airway inflammatory response by promoting vascular permeability. Furthermore, it is known that Allium hookeri and one
M Di Giovangiulio et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(11), 1542-1552 (2015-08-01)
The orexigenic peptide ghrelin has anti-inflammatory properties in colitis, however, the mechanism of action and the immune cells targeted remain still to be elucidated. Here, we assessed the possible effect of ghrelin on T helper (Th) cells in a T
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