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Curt T Dellavalle et al.
International journal of cancer, 134(12), 2917-2926 (2013-11-19)
Nitrate and nitrite are precursors of endogenously formed N-nitroso compounds (NOC), known animal carcinogens. Nitrosation reactions forming NOCs can be inhibited by vitamin C and other antioxidants. We prospectively investigated the association between dietary nitrate and nitrite intake and risk
Rebecca L Dahlin et al.
Annals of biomedical engineering, 42(7), 1381-1390 (2013-07-12)
In this study, we investigated the effect of flow perfusion culture on the mineralization of co-cultures of human umbilical vein endothelial cells (HUVECs) and human mesenchymal stem cells (hMSCs). Osteogenically precultured hMSCs were seeded onto electrospun scaffolds in monoculture or
Yong-Gil Kim et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(10), 2793-2803 (2014-07-02)
Although ankylosing spondylitis (AS) is driven by immune-mediated processes, little is known about the presence and role of autoantibodies in this disease. This study was undertaken to investigate whether autoantibodies occur in and are involved in AS. We performed human
Wei-Li Fu et al.
Tissue engineering. Part A, 21(5-6), 948-959 (2014-10-10)
Vascularization of engineered bone tissue is critical for ensuring its survival after implantation and it is the primary factor limiting its clinical use. A promising approach is to prevascularize bone grafts in vitro using endothelial progenitor cells (EPC) derived from
Tanya Zappitelli et al.
Molecular biology of the cell, 26(5), 832-842 (2015-01-09)
Gja1(Jrt)/+ mice carry a mutation in one allele of the gap junction protein α1 gene (Gja1), resulting in a G60S connexin 43 (Cx43) mutant protein that is dominant negative for Cx43 protein production of <50% of wild-type (WT) levels and
Bakr F Abdel-Wahab et al.
European journal of medicinal chemistry, 46(5), 1505-1511 (2011-03-01)
In the present work, 1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethanone 1 was prepared and used as a precursor for the synthesis of new thiazole, arylidiene and coumarin derivatives. The antimicrobial, antioxidant, anti-hemolytic, and cytotoxic activities of new compounds have been screened. Compound 12 showed an
Yang Ho Kang et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 19(2), 111-118 (2015-03-03)
Osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL)/receptor activator of NF-κB (RANK) axis, and TNF-related apoptosis-inducing ligand (TRAIL) participate in vascular calcification process including atherosclerosis, but their contributions under high glucose (HG) and phosphate (HP) condition for a long-term period
Hyung Ho Yoon et al.
Journal of Korean medical science, 29(11), 1555-1561 (2014-11-20)
A double toxin-double lesion strategy is well-known to generate a rat model of striatonigral degeneration (SND) such as multiple system atrophy-parkinsonian type. However, with this model it is difficult to distinguish SND from Parkinson's disease (PD). In this study, we
Yang-peng Sun et al.
PloS one, 9(7), e101896-e101896 (2014-07-09)
Multipotent mesenchymal stem cells (MSCs) found in the synovial fluid (SFMSCs) of the tempromandibular joint (TMJ) remain poorly understood. During TMJ arthrocentesis, we discovered that synovial fluid collected from some patients with TMJ disorders contained not only SFMSCs but also
Tomohito Sato et al.
PloS one, 10(2), e0117020-e0117020 (2015-02-05)
Ascorbic acid is an effective antioxidant and free radical scavenger. Therefore, it is expected that ascorbic acid should act as a radioprotectant. We investigated the effects of post-radiation treatment with ascorbic acid on mouse survival. Mice received whole body irradiation
Bo-Ram Kim et al.
Tissue engineering. Part A, 20(23-24), 3279-3289 (2014-06-18)
To confirm the effect of recombinant human bone morphogenetic protein-2 (BMP-2) for bone regeneration, BMP-2-loaded polycaprolactone (PCL)-gelatin (Gel)-biphasic calcium phosphate (BCP) fibrous scaffolds were fabricated using the electrospinning method. The electrospinning process to incorporate BCP nanoparticles into the PCL-Gel scaffolds
Steven M Presciutti et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(9), 1181-1188 (2014-05-21)
Degeneration of the intervertebral disc (IVD) results in deterioration of the spinal motion segment and can lead to debilitating back pain. Given the established mitotic and anti-apoptotic effects of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in a variety of cell
Gene L Bowman
BioFactors (Oxford, England), 38(2), 114-122 (2012-03-16)
This narrative review appraises the human and animal studies implicating ascorbic acid (AA) in normal cognitive function and Alzheimer's disease. A research framework for how nutrition affects brain aging is proposed with emphasis on AA intake, status, metabolism, and transport
Abdullah Ozer et al.
Nature chemical biology, 3(3), 144-153 (2007-02-16)
Members of the Fe(II)- and 2-oxoglutarate-dependent family of dioxygenases have long been known to oxidize several amino acids in various protein targets to facilitate protein folding. However, in recent years investigators have characterized several such hydroxylation modifications that serve a
Yejing Liu et al.
Small (Weinheim an der Bergstrasse, Germany), 10(23), 4940-4950 (2014-07-23)
A major challenge in plasmonic hot spot fabrication is to efficiently increase the hot spot volumes on single metal nanoparticles to generate stronger signals in plasmon-enhanced applications. Here, the synthesis of designer nanoparticles, where plasmonic-active Au nanodots are selectively deposited
Lizette Utomo et al.
Biomedical materials (Bristol, England), 10(1), 015010-015010 (2015-01-15)
Scaffolds are widely used to reconstruct cartilage. Yet, the fabrication of a scaffold with a highly organized microenvironment that closely resembles native cartilage remains a major challenge. Scaffolds derived from acellular extracellular matrices are able to provide such a microenvironment.
Ying Wang et al.
European journal of nutrition, 53(6), 1363-1369 (2013-12-18)
Previous studies have shown that total antioxidant capacity (TAC) of typical diets is associated with higher plasma TAC and antioxidant enzyme activities. At present, however, little is known for the association between dietary TAC and inflammatory biomarkers. The present study
Hee Geun Yoo et al.
Journal of medicinal food, 17(11), 1189-1196 (2014-08-20)
Oxidative stress damages dermal and epidermal cells and degrades extracellular matrix proteins, such as collagen, ultimately leading to skin aging. The present study evaluated the potential protective effect of the aqueous methanolic extract obtained from Lithospermum erythrorhizon (LE) against oxidative
Tadashi Goto et al.
Cytotechnology, 67(2), 357-365 (2014-02-07)
Polyphenol have been reported to have physiological effects with respect to alleviating diseases such as osteoporosis and osteopetrosis. We recently reported that the olive polyphenol hydroxytyrosol accelerates bone formation both in vivo and in vitro. The present study was designed
Xiao-Qing Zhang et al.
Methods in molecular biology (Clifton, N.J.), 584, 355-366 (2009-11-13)
Directed differentiation of human embryonic stem cells (hESCs) to a functional cell type, including neurons, is the foundation for application of hESCs. We describe here a reproducible, chemically defined protocol that allows directed differentiation of hESCs to nearly pure neuroectodermal
Hong Seok Choi et al.
Diseases of the colon and rectum, 57(10), 1220-1227 (2014-09-10)
Many patients report discomfort because of the unpleasant taste of bowel preparation solutions. This study aimed to determine whether adding orange juice to 2 L of polyethylene glycol plus ascorbic acid is effective for reducing patient discomfort and improving palatability
Jane Ru Choi et al.
Biochemical and biophysical research communications, 448(2), 218-224 (2014-05-03)
Adipose-derived stem cells (ASCs) have been found adapted to a specific niche with low oxygen tension (hypoxia) in the body. As an important component of this niche, oxygen tension has been known to play a critical role in the maintenance
Susan J Zunino et al.
The British journal of nutrition, 112(3), 369-380 (2014-05-17)
Obese individuals are at an increased risk of developing CVD, hypertension, type 2 diabetes, and bacterial and viral infections when compared with the normal-weight population. In a 9-week randomised, double-blind, cross-over study, twenty-four obese subjects aged between 20 and 60
Francesca Veronesi et al.
Cytotherapy, 17(2), 215-223 (2014-12-09)
Tendon is a complex tissue with a reduced regenerative ability. Nowadays, little or nothing is known about the regenerative effect of adipose-derived mesenchymal stromal cells (ADSCs) on tendons. The study aimed to evaluate the in vitro mutual interaction of ADSCs
Chee Shan Lim et al.
Physical chemistry chemical physics : PCCP, 16(24), 12178-12182 (2014-05-13)
Graphene materials are very popular in the field of biosensing owing to their distinctive characteristics. However, oxygen-containing groups are known to exist intrinsically in graphene-related materials. These groups influence the electrochemical properties of graphene materials and therefore affect the sensing
Cecilia Granéli et al.
Stem cell research, 12(1), 153-165 (2013-11-19)
Today, the tool that is most commonly used to evaluate the osteogenic differentiation of bone marrow stromal cells (BMSCs) in vitro is the demonstration of the expression of multiple relevant markers, such as ALP, RUNX2 and OCN. However, as yet
Hua Huang et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(47), 18666-18670 (2007-11-16)
Hepatitis C virus (HCV) is a single-stranded positive-sense RNA virus of the Flaviviridae family. HCV-infected hepatocytes are known to produce reactive oxygen species (ROS), which initiate lipid peroxidation, a reaction that converts polyunsaturated fatty acids, such as arachidonate, into reactive
Zhu-Xu Zhang et al.
Transplantation, 98(10), 1029-1039 (2014-10-07)
Approximately 50% of cardiac transplants fail in the long term, and currently, there are no specific treatments to prevent chronic rejection. In the clinic, donor cardiac graft ischemia time is limited to within a few hours and correlates with delayed
Joan Chang et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(7), 1789-1799 (2014-02-28)
To investigate the role of hypoxia in the pathology of osteoarthritic (OA) bone by exploring its effect on the phenotype of isolated primary osteoblasts from patients with knee OA. OA bone samples were collected at the time of elective joint
Shuang Yang et al.
BMC molecular biology, 16, 1-1 (2015-04-19)
The glomerular podocyte is a highly specialized cell type with the ability to ultrafilter blood and support glomerular capillary pressure. However, little is known about the genetic programs leading to this functionality or the final phenotype. In the current study
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