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Keith G Davies et al.
The Journal of experimental biology, 218(Pt 5), 778-785 (2015-01-27)
Ambient exposure to a short synthetic peptide has enhanced fecundity (number of offspring) in invertebrates and vertebrates, ostensibly by disinhibiting reproduction. In separate experiments, nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) were exposed via their aqueous environment to a
Niwanthi W Rajapakse et al.
Current opinion in nephrology and hypertension, 22(1), 45-50 (2012-10-26)
L-Arginine (L-Arg) is the substrate for nitric oxide (NO) formation. Reduced NO bioavailability, particularly within the renal circulation, has been identified as a key factor in the pathogenesis of hypertension. This review focuses on the pathogenic role of abnormal L-Arg
Joern Lausen
Critical reviews in eukaryotic gene expression, 23(3), 265-274 (2013-07-25)
Hematopoietic differentiation is directed by transcription factors such as RUNX1. RUNX1 binds to specific DNA binding sites in regulatory elements of genes and recruits epigenetic cofactors to target loci. In this way histone modification patterns and the chromatin environment are
N M Violato et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(9), 615-620 (2014-03-20)
Insulin secretion is mainly regulated by blood glucose concentration. On the other hand, changes in peripheral insulin sensitivity induce compensatory adaptations in pancreatic β-cells to maintain normoglycaemia. Tumour presence causes dramatic alterations in glucose homeostasis and insulin secretion because of
Vladimir Tolstikov et al.
PloS one, 9(12), e114019-e114019 (2014-12-09)
Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in cellular bioenergetics. It is responsible for converting nicotinamide to nicotinamide adenine dinucleotide, an essential molecule in cellular metabolism. NAMPT has been extensively studied over the past decade due to its role as
Yoshitomo Notsu et al.
Atherosclerosis, 239(1), 61-66 (2015-01-13)
Asymmetric dimethylarginine (ADMA), which acts an endogenous inhibitor of nitric oxide synthase (NOS), is involved in the pathogenesis of cardiovascular disease. Arginine (Arg) may regulate vascular endothelial function, since Arg is the substrate of NO competing with ADMA. In our
Graziano Colombo et al.
Biochimica et biophysica acta, 1850(1), 1-12 (2014-10-05)
Advanced oxidation protein products (AOPPs) are dityrosine cross-linked and carbonyl-containing protein products formed by the reaction of plasma proteins with chlorinated oxidants, such as hypochlorous acid (HOCl). Most studies consider human serum albumin (HSA) as the main protein responsible for
Vítor M Gaspar et al.
Pharmaceutical research, 32(2), 562-577 (2014-09-05)
Tumor targeting nanomaterials have potential for improving the efficiency of anti-tumoral therapeutics. However, the evaluation of their biological performance remains highly challenging. In this study we describe the synthesis of multifunctional nanoparticles decorated with folic acid-PEG and dual amino acid-modified
Roberto Maya-Martinez et al.
Biochemical and biophysical research communications, 456(2), 695-699 (2014-12-20)
AL amyloidosis is the most common amyloid systemic disease and it is characterized by the deposition of immunoglobulin light chain amyloid fibers in different organs, causing organ failure. The immunoglobulin light chain germinal line 6a has been observed to over-express
James A Cotton et al.
Infection and immunity, 82(7), 2772-2787 (2014-04-16)
Giardia duodenalis (syn. G. intestinalis, G. lamblia) infections are a leading cause of waterborne diarrheal disease that can also result in the development of postinfectious functional gastrointestinal disorders via mechanisms that remain unclear. Parasite numbers exceed 10(6) trophozoites per centimeter
Yvette C Luiking et al.
American journal of physiology. Endocrinology and metabolism, 303(10), E1177-E1189 (2012-09-27)
Arginine is derived from dietary protein intake, body protein breakdown, or endogenous de novo arginine production. The latter may be linked to the availability of citrulline, which is the immediate precursor of arginine and limiting factor for de novo arginine
Fruzsina K Johnson et al.
Obesity (Silver Spring, Md.), 23(2), 383-390 (2015-01-06)
This study investigated whether arginase contributes to endothelial dysfunction and hypertension in obese rats. Endothelial function and arginase expression were examined in skeletal muscle arterioles from lean and obese Zucker rats (ZRs). Arginase activity, arginine bioavailability, and blood pressure were
Shuyu Wang et al.
Science (New York, N.Y.), 347(6218), 188-194 (2015-01-09)
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag-, Ragulator-, and vacuolar adenosine triphosphatase-dependent fashion, the translocation of mTORC1 to the lysosomal
Qinglin Han et al.
Journal of virology, 88(16), 9379-9390 (2014-06-13)
Viruses take advantage of host posttranslational modifications for their own benefit. It was recently reported that influenza A virus proteins interact extensively with the host sumoylation system. Thereby, several viral proteins, including NS1 and M1, are sumoylated to facilitate viral
Juliana P Paiva et al.
Journal of pharmaceutical sciences, 103(8), 2539-2545 (2014-06-20)
Photoprotective potential and biological consequences (mutagenic potential) of octyl-dimethyl-PABA (ODP), titanium dioxide (TiO2 ), and montmorillonite (MMT) upon ultraviolet B (UVB) irradiation, alone and in different associations [physical mixtures (PMs)], were evaluated using a Saccharomyces cerevisiae ogg1 mutant (deficient) strain.
PRRT2 and hemiplegic migraine: a complex association.
Nadine Pelzer et al.
Neurology, 83(3), 288-290 (2014-06-15)
Tomohisa Suematsu et al.
Biochemical and biophysical research communications, 453(3), 588-594 (2014-10-07)
Mitotic catastrophe, a form of cell death that occurs during mitosis and after mitotic slippage to a tetraploid state, plays an important role in the efficacy of cancer cell killing by microtubule inhibitors. Prolonged mitotic arrest at the spindle assembly
Rui Zhang et al.
Vaccine, 32(25), 3107-3114 (2014-01-28)
Mycoplasma bovis is a major etiological agent of pneumonia and arthritis in feedlot beef cattle. To develop a novel live vaccine against M. bovis, two attenuated M. bovis strains, P150 and P180, were tested in calves for protection against challenge
Chih-Min Tsai et al.
Translational research : the journal of laboratory and clinical medicine, 164(6), 452-459 (2014-08-30)
Elevated asymmetric dimethylarginine (ADMA) levels and nitric oxide (NO) deficiency are associated with the development of hypertension. Metformin, an antidiabetic agent, is a structural analog of ADMA. We examined whether metformin can prevent the development of hypertension in spontaneously hypertensive
Takao Kohno et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(11), 4776-4787 (2015-03-20)
During brain development, Reelin exerts a variety of effects in a context-dependent manner, whereas its underlying molecular mechanisms remain poorly understood. We previously showed that the C-terminal region (CTR) of Reelin is required for efficient induction of phosphorylation of Dab1
Surgery, 156(4), 869-870 (2014-09-23)
Xiaolian Sun et al.
ACS nano, 8(8), 8438-8446 (2014-07-16)
Using positron emission tomography (PET) imaging to monitor and quantitatively analyze the delivery and localization of Au nanomaterials (NMs), a widely used photothermal agent, is essential to optimize therapeutic protocols to achieve individualized medicine and avoid side effects. Coupling radiometals
Q Qi et al.
Oncogene, 33(41), 4893-4903 (2013-10-30)
Merlin, encoded by the Neurofibromatosis 2 (NF2) gene, is a multifunctional tumor suppressor that integrates and regulates extracellular cues and intracellular signaling pathways, both at the plasma membrane and in the nucleus, to control cell proliferation, migration and invasion. Molecular
Feng Wang et al.
Toxicology letters, 229(1), 229-239 (2014-07-01)
Trichloroethylene (TCE) is a major occupational health hazard and causes occupational medicamentosa-like dermatitis (OMLDT) and liver damage. Recent evidence suggests immune response as a distinct mode of action for TCE-induced liver damage. This study aimed to explore the role of
Roshani Patel et al.
Biochimica et biophysica acta, 1843(8), 1620-1628 (2014-03-04)
The twin-arginine translocation (Tat) system accomplishes the remarkable feat of translocating large - even dimeric - proteins across tightly sealed energy-transducing membranes. All of the available evidence indicates that it is unique in terms of both structure and mechanism; however
Arminja N Kettenbach et al.
Journal of proteomics, 114, 48-60 (2014-12-03)
The study of cellular signaling remains a significant challenge for translational and clinical research. In particular, robust and accurate methods for quantitative phosphoproteomics in tissues and tumors represent significant hurdles for such efforts. In the present work, we design, implement
Zilin Nie et al.
Nature communications, 6, 5908-5908 (2015-01-09)
MALT1 is the only known paracaspase and is a critical mediator of B- and T-cell receptor signalling. The function of the MALT1 gene is subverted by oncogenic chimeric fusions arising from the recurrent t(11;18)(q21;q21) aberration, which is the most frequent
Ying Zhou et al.
The Analyst, 139(12), 3122-3126 (2014-05-03)
A new type of rapid, sensitive, and selective fluorescence turn-on assay was developed for detection of histidine using a DNA-scaffolded silver nanocluster/Cu(2+) ensemble (DNA-AgNC/Cu(2+)). Cu(2+) was first bound to nucleic acids of the DNA-AgNCs forming a DNA-AgNC/Cu(2+) ensemble and then
Giulia Brigante et al.
European journal of endocrinology, 170(5), 685-696 (2014-02-19)
Gender influence on GH secretion in human immunodeficiency virus (HIV)-infected patients is poorly known. To determine the effect of gender, we compared GH response to GH-releasing hormone plus arginine (GHRH+Arg), and body composition in 103 men and 97 women with
Qingyong Ma et al.
Current pharmaceutical design, 16(4), 392-410 (2010-03-20)
The action of L-arginine is mainly dependent on its end-product, nitric oxide (NO). The L-arginine/NO pathway has been confirmed to play an important role in tumor development. Recent findings indicate that NO derived from L-arginine could influence angiogenesis factors, vascular
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